MCE 1,3-Distearin ≥98.0%

1,3-Distearin, also known as 1,3-Distearoyl glycerol, is a diacylglycerol (DAG) lipid composed of two stearic acid (C18:0) chains esterified at the sn-1 and sn-3 positions of the glycerol backbone, with a free hydroxyl group at the sn-2 position.

This compound is a valuable synthetic intermediate widely used in medicinal chemistry and pharmaceutical research, particularly in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs). In addition, 1,3-Distearin is relevant in lipid chemistry and metabolic research, where defined diacylglycerols are used to study lipid structure, reactivity, and biological function.

Intended Use

• For research use only (RUO)
• Not for human or veterinary use
• Intended for:
  • Pharmaceutical and medicinal chemistry research
  • Synthesis of NSAID intermediates
  • Lipid chemistry and diacylglycerol studies
  • Organic synthesis and method development

Chemical & Physical Properties

Chemical Structure Information

• SMILES:
  CCCCCCCCCCCCCCCCCC(OCC(O)COC(CCCCCCCCCCCCCCCCC)=O)=O

The structure features two long-chain saturated fatty acids and a free secondary hydroxyl group, making it chemically reactive and suitable for downstream functionalization.

Functional & Research Significance

Pharmaceutical & Medicinal Chemistry

1,3-Distearin is commonly used as an intermediate in the synthesis of NSAIDs, including:

• Ibuprofen
• Naproxen
• Diclofenac
• Related non-steroidal anti-inflammatory agents

Its defined structure enables controlled esterification, substitution, and derivatization in synthetic pathways.

Lipid Chemistry

• Serves as a model diacylglycerol for studying:
  • Lipid reactivity
  • Structure–function relationships
  • DAG metabolism and signaling
• Useful in comparative studies with:
  • 1,2-Distearoyl-sn-glycerol
  • Triacylglycerols (TAGs)
  • Phospholipid precursors

Applications

• NSAID synthesis and drug development research
• Organic synthesis intermediate
• Diacylglycerol and lipid chemistry studies
• Medicinal chemistry method development
• Lipid metabolism and signaling research

Packaging & Available Sizes

Storage & Stability

Key Advantages

• High purity (≥98.0%)
• Well-defined diacylglycerol structure
• Ideal synthetic intermediate for NSAIDs
• Suitable for advanced medicinal chemistry research
• Available in multiple small-quantity pack sizes

Comparison Note

• 1,3-Distearin (this product): Free sn-2 hydroxyl, high synthetic versatility
• 1,2-Distearoyl-sn-glycerol: Fully esterified sn-1/sn-2 DAG, commonly used as lipidomics standard
• Triacylglycerols: No free hydroxyl, lower synthetic flexibility

1,3-Distearin (1,3-Distearoyl glycerol) is a high-purity research compound with significant value in pharmaceutical synthesis, medicinal chemistry, and lipid research. Its dual role as a synthetic intermediate for NSAIDs and a model diacylglycerol makes it an essential reagent for laboratories working in drug development and lipid chemistry.