Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer

The Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer is a powerful, easy-to-use LC-MS system designed to bring mass spectrometry capability into routine analytical laboratories. With seamless LC integration, extended mass range, dual ionization capabilities, and intuitive software control, the ISQ EM enables both novice and experienced users to unlock the full analytical potential of LC-MS with minimal training and maximum productivity.

This robust single quadrupole system supports Heated Electrospray Ionization (HESI) and Atmospheric Pressure Chemical Ionization (APCI) through interchangeable probes, allowing laboratories to analyze a wide diversity of compounds—including small molecules, metabolites, organic acids, pharmaceuticals, environmental contaminants, food analytes, and more.

Whether used for quantitation, identity confirmation, peak purity assessment, or elimination of false positives/negatives, the ISQ EM delivers the sensitivity, linearity, and stability required for reliable everyday LC-MS workflows.

Key Performance Advantages

1. Dual Ionization for Maximum Application Flexibility

• Includes both HESI and APCI probes
• Switch ionization modes quickly for different classes of analytes
• Ideal for polar, semi-polar, and non-polar compounds
• Supports broad applications across pharma, food safety, environmental testing, and research

2. Extended Mass Range for Broader Detection

• Mass range 10–2000 m/z
• Allows detection of small organic molecules, peptides, and mid-sized molecules
• Unit mass resolution ensures sharp, accurate mass peaks

3. High Sensitivity for Low-Level Detection

HESI Mode Sensitivities:

• Positive: 10 pg reserpine, 400:1 RMS
• Negative: 20 pg p-nitrophenol, 500:1 RMS

APCI Mode Sensitivities:

• Positive: 10 pg reserpine, 1000:1 RMS
• Negative: 20 pg p-nitrophenol, 80:1 RMS

Detect trace-level analytes with high reproducibility and excellent signal-to-noise ratios.

4. Fast Polarity Switching

• 25 ms polarity switching for both HESI and APCI
• Enhances productivity in multi-analyte workflows
• Supports efficient screening of complex samples

5. Reliable Quantitation & Peak Confirmation

• Achieve accurate quantitation even in complex matrices
• Confirm chromatographic peaks using mass spectral data
• Eliminate false positives and false negatives
• Resolve co-eluting compounds via mass-to-charge discrimination

6. Integrated, User-Friendly Software

• Controlled directly through Thermo Scientific™ Chromeleon™ CDS
• Ideal for both novice and expert users
• Built-in tools translate analyte properties into optimized MS settings
• Streamlines method development and reduces training time

Applications

• Pharmaceutical QC and R&D
• Environmental testing
• Food & beverage safety
• Clinical and forensic analysis
• Chemical identification and purity confirmation
• Routine LC–MS quantification
• Peak purity and co-elution resolution

Specifications

The Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer is a robust, dual-ionization LC-MS system offering extended mass range, superior sensitivity, fast polarity switching, and seamless Chromeleon™ CDS integration. Ideal for routine LC-MS quantitation, peak confirmation, impurity analysis, and method development across pharmaceutical, environmental, food, and research laboratories.