Invitrogen™ Dynabeads™ Streptavidin for Target Enrichment

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Specifications:

Application	Next Generation Sequencing
Storage Temperature	2-8°C
Product Type	Sequencing Reagents	Forms	Liquid
Product Brand	Thermo Fisher Scientific™
Product Grade	Molecular Biology

Overview
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The Invitrogen™ Dynabeads™ Streptavidin for Target Enrichment are 1-μm superparamagnetic, monosized, and monodispersed beads designed for efficient target sequence enrichment in next-generation sequencing (NGS) workflows. Covalently coupled with a high-quality streptavidin monolayer, these beads deliver superior binding performance, reproducibility, and high-throughput compatibility—ensuring sensitive and accurate NGS library preparations.

Optimized for the specific capture of biotinylated nucleic acid targets, the beads support high-yield and high-purity enrichment across a variety of sample types, and are fully automation-compatible with KingFisher™ purification systems and other liquid handling platforms.

Key Features

High Sensitivity and Reproducibility

Monosized 1-μm beads with <5% size distribution for consistent performance and minimal variability across batches.
Defined streptavidin monolayer maximizes available biotin-binding sites and ensures reproducible enrichment efficiency.

High Binding Capacity

Each 1 mg of beads can bind:
- 950–1,500 pmol free biotin
- ~20 µg of biotinylated double-stranded DNA
- ~400 pmol of biotinylated single-stranded oligonucleotides

Superior Target Enrichment for NGS

Enables specific hybridization via biotinylated capture probes, followed by magnetic separation and elution.
Yields high-purity, target-enriched DNA ideal for robust and confident variant detection.

Automation Ready

Compatible with KingFisher™ Sample Purification Systems for high-throughput, walk-away processing.
Scalable from manual to automated workflows without loss in performance.

Reliable, Phenol-Free Workflow

Non-toxic, clean-up friendly process suitable for sensitive downstream applications like NGS, PCR, qPCR, and ChIP-Seq.

Specifications

Attribute	Details
Bead Type	Superparamagnetic, monosized, monodispersed
Bead Size	1 μm
Surface Coating	Covalently coupled streptavidin monolayer
Binding Capacity	950–1,500 pmol biotin / mg beads 20 µg dsDNA / mg 400 pmol ssDNA / mg
Target Molecules	Biotinylated nucleic acids (dsDNA, ssDNA, oligonucleotides)
Applications	NGS target enrichment, hybrid capture, library preparation, ChIP, PCR
For Use With Equipment	KingFisher™ Flex, Apex, Duo Prime; compatible liquid handlers
Purification Technology	Magnetic bead–based target capture
Automation Compatibility	Yes
Storage Conditions	2–8 °C (Do not freeze)
Unit Size	Custom volumes available; contact supplier

Comparison with Related Dynabeads™ Streptavidin Beads

Product	Bead Size	Surface	Best For	Binding Capacity
Dynabeads™ Streptavidin for Target Enrichment	1 μm	Streptavidin monolayer	Target enrichment for NGS workflows	950–1,500 pmol biotin/mg
Dynabeads™ M-280 Streptavidin	2.8 μm	Streptavidin	General biotin capture, protein-protein studies	~200–300 pmol biotin/mg
Dynabeads™ MyOne™ Streptavidin C1	1 μm	Streptavidin	High surface area, low background assays	~650–900 pmol biotin/mg
Dynabeads™ Biotin Binder	2.8 μm	Biotin-specific ligand	Protein and antibody pull-down assays	~300 pmol biotin/mg

Unique Advantages of Dynabeads™ Streptavidin for Target Enrichment

High confidence in NGS variant calling due to superior coverage and target specificity.
Reduced variability and higher batch-to-batch consistency with monosized, low-dispersion beads.
Versatile workflow integration for both manual and automated enrichment processes.
Optimized hybridization and wash conditions enable high-purity target DNA recovery.
Ideal pairing with MagMAX™ Pure Bind Beads for downstream NGS library cleanup and preparation.