Apollo Sci. Oligomycin A from Streptomyces diastatochromogenes

Oligomycin is a macrolide antibiotic derived from Streptomyces diastatochromogenes that specifically inhibits membrane-bound mitochondrial ATPase, a key enzyme in ATP synthesis. By inhibiting this enzyme, oligomycin interferes with the production of ATP, making it useful in studying mitochondrial function and energy metabolism.

Chemical Properties:

• Formula: C₄₅H₇₄O₁₁
• Molecular Weight (MW): 789.3 g/mol
• Melting Point: 150°C
• Storage Temperature: Freezer (Recommended for long-term storage)
• MDL Number: MFCD01779388
• CAS Number: 1404-19-9
• UN Number: 2811 (Toxic substances)
• ADR Classification: 6.1 (Toxic), Hazard Class III (Moderate hazard)

Available Packaging:

Applications

• Research: Used primarily in biological research to study mitochondrial ATPase inhibition and its effects on cellular energy production.
• Drug Development: Investigated in the development of treatments targeting mitochondrial diseases and cancer therapies.

Safety and Handling

• Oligomycin should be handled with care, as it is toxic (ADR 6.1), and appropriate protective equipment should be used when handling the compound. Ensure it is stored at appropriate temperatures in a freezer to maintain stability.