Apollo Sci. Hydrochlorothiazide

Hydrochlorothiazide is a well-known thiazide diuretic compound widely used in pharmaceutical research related to hypertension, edema, and cardiovascular disease. It inhibits sodium/chloride symporters in the distal convoluted tubule of the kidney, thereby promoting the excretion of sodium and water, and reducing blood volume and pressure.

Apollo Scientific offers high-purity Hydrochlorothiazide in convenient pack sizes for research and chemical synthesis. This compound is supplied as a stable off-white to light yellow powder and conforms to quality standards suitable for laboratory research and development.

Available Pack Sizes

Key Specifications

Applications in Research

• Antihypertensive Drug Studies
  Hydrochlorothiazide is a first-line agent used in modeling the treatment of essential hypertension.
• Renal and Diuretic Pharmacology
  Investigated for its effects on electrolyte transport, urine formation, and volume regulation.
• Drug Combination Research
  Frequently co-administered in combination therapy trials with ACE inhibitors, ARBs, or beta-blockers.
• Metabolic Side Effects Studies
  Evaluated for its role in glucose intolerance, lipid profile changes, and electrolyte imbalance.

Biochemical Activity

• Mechanism of Action: Inhibits Na⁺/Cl⁻ symporters in the renal distal tubule
• Pharmacological Class: Thiazide diuretic
• Biological Effects:
  • Promotes natriuresis and diuresis
  • Reduces plasma volume and cardiac output
  • Decreases peripheral vascular resistance

Apollo Scientific Hydrochlorothiazide is a high-quality, research-grade thiazide diuretic compound trusted for cardiovascular, renal, and pharmacokinetic research. Supplied in ambient-stable packaging and available in multiple convenient pack sizes, it serves as an essential reference material for drug development, therapeutic modeling, and mechanistic studies in hypertension and fluid-electrolyte balance.