VWR® Methanol-[D₄] (99.8% D) for NMR spectroscopy

VWR® Methanol-d₄ (CD₃OD) is a high-purity deuterated solvent designed for nuclear magnetic resonance (NMR) spectroscopy, particularly suited for polar and hydrophilic compounds.

With ≥99.8% deuterium enrichment and ≥99.9% purity, Methanol-d₄ provides minimal proton background interference and a stable field-frequency lock signal, enabling high-resolution ¹H, ¹³C, and multidimensional NMR analysis.

Key Features & Benefits

1. High Isotopic Enrichment for NMR Precision

• ≥99.8% D ensures:
  • Reduced proton signal interference
  • Stable and reliable instrument lock

2. Ultra-High Purity

• Assay: ≥99.9% (anhydrous)
• Water content: ≤0.03%
• Enables clean spectra and reproducible results

3. Ideal for Polar Compounds

• Excellent solubility for:
  • Polar organic molecules
  • Biomolecules and metabolites
  • Pharmaceutical compounds

4. Broad NMR Compatibility

• Suitable for:
  • ¹H NMR
  • ¹³C NMR
  • 2D NMR (COSY, HSQC, HMBC)

5. Flexible Packaging Options

• Available in:
  • Sealed ampoules (10 × 0.6 mL)
  • Glass bottles and septum-cap bottles (10–100 mL)
• Ensures convenience and contamination control

Applications

• Structural elucidation of polar compounds
• Pharmaceutical and metabolomics research
• Natural product and biochemical analysis
• Reaction monitoring in polar media
• Quantitative NMR (qNMR) studies

Technical Specifications

Ordering Information

Analytical Significance

Methanol-d₄ is preferred for NMR when:

• Analytes are polar or water-soluble
• Other solvents (e.g., CDCl₃) are unsuitable
• Exchangeable protons (e.g., –OH, –NH) need to be studied

It provides:

• A stable deuterium lock signal
• Minimal interference in ¹H NMR spectra
• Compatibility with biochemical and pharmaceutical samples

Hazard Information

⚠️ Classification: Flammable, Toxic

• UN Number: 1230
• ADR Class: 3 (Flammable) / 6.1 (Toxic)

Handle with appropriate PPE, avoid inhalation and ingestion, and use in a fume hood.

Unique Advantages

• Ideal for polar compound NMR analysis
• High isotopic purity for accurate spectral interpretation
• Multiple packaging options for flexibility and convenience
• Compatible with advanced NMR techniques
• Reliable quality from Avantor

VWR® Methanol-d₄ (99.8% D) is a versatile and high-performance NMR solvent, essential for analyzing polar and hydrophilic compounds. Its high purity, isotopic enrichment, and excellent solvation properties make it a key reagent for modern NMR spectroscopy workflows in research and analytical laboratories.