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Sigma-Aldrich™ Fmoc-Arg(Pbf)-OH, ≥98.0% (HPLC)
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Specifications:
| Application | Protein Biology, Peptide Synthesis | ||
| Storage Temperature | -20°C | ||
| Product Type | Amino Acid & Biochemicals | Forms | Powder |
| Product Brand | Sigma-Aldrich | ||
| Product Grade | HPLC Grade | Formula | C₃₁H₄₀N₄O₈ |
Fmoc-Arg(Pbf)-OH is a high-purity, selectively protected arginine derivative designed for Fmoc-based solid-phase peptide synthesis (SPPS). It contains an Fmoc-protected N-terminal amine and a Pbf-protected guanidino side chain, allowing controlled peptide chain elongation and selective side-chain deprotection during final cleavage.
This reagent is widely used in custom peptide synthesis, pharmaceutical research, proteomics, drug discovery, protein engineering, and bioorganic chemistry. Its high purity and stable protecting-group chemistry make it suitable for efficient incorporation of arginine residues into synthetic peptides.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Dual Protection | Fmoc protection on the α-amino group and Pbf protection on the arginine side chain |
| SPPS Compatible | Suitable for Fmoc-based solid-phase peptide synthesis workflows |
| Selective Deprotection | Pbf group is removable under acidic cleavage conditions, commonly using TFA |
| Research Grade | Ideal for peptide chemistry, drug discovery, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Arg(Pbf)-OH, ≥98.0% HPLC |
| CAS Number | 154445-77-9 |
| Empirical Formula | C₃₄H₄₀N₄O₇S |
| Molecular Weight | 648.77 g/mol |
| Beilstein Registry Number | 8302671 |
| MDL Number | MFCD00235804 |
| PubChem Substance ID | 57650929 |
| Optical Activity | [α]/D -5.5 ± 1.0°; c = 1 in DMF |
| Form | Powder or crystals |
| Assay | ≥98.0% by HPLC |
| Storage Temperature | -20 °C |
| Functional Groups | Fmoc, amine, guanidino, carboxylic acid |
Applications
Fmoc-Arg(Pbf)-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of arginine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based drug discovery and therapeutic research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Bioorganic chemistry and peptidomimetic synthesis
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47349-5G | 5 g |
| 47349-25G | 25 g |
| 47349-100G | 100 g |
| 47349-1KG | 1 kg |
Storage & Handling
Store at -20 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and repeated freeze-thaw cycles. Handle only in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
- Pack Size: 1kg 100g 5g 25g