Specifications:
| Application | cell Signalling | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Apollo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₂₇H₃₈N₂O₄ |
Apollo Scientific Verapamil Hydrochloride is a high-purity calcium channel blocker used as a pharmaceutical reference standard and biochemical research compound. It functions by inhibiting calcium ion influx through slow calcium channels, reducing myocardial contractility and vascular tone.
This compound is widely utilized in cardiovascular pharmacology research, particularly in studies involving hypertension, angina pectoris, arrhythmia, and smooth muscle relaxation. It is also applied in drug metabolism, receptor binding assays, and analytical method development.
Chemical Information
| Property | Details |
|---|---|
| Chemical Name | Verapamil Hydrochloride |
| Synonyms | 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride; Verapamil HCl; (±)-Verapamil hydrochloride |
| Chemical Formula | C₂₇H₃₈N₂O₄·HCl |
| Molecular Weight | 491.07 g/mol |
| CAS Number | 152-11-4 |
| MDL Number | MFCD00055208 |
| EINECS | 205-800-5 |
| UN Number | 2811 |
| ADR Classification | 6.1, III (Toxic Substance) |
| Storage Temperature | Refrigerator (2–8 °C) |
| Hazard Classification | Toxic |
Physical and Chemical Properties
| Property | Value |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity (Assay) | Typically ≥98% (pharmaceutical grade) |
| Solubility | Freely soluble in water and ethanol |
| Stability | Stable under recommended storage conditions |
| Odor | Odorless |
| Melting Point | 140–145 °C (approx.) |
| Grade | Analytical / Pharmaceutical Reference Standard |
Applications
- Pharmacological research on calcium channel modulation.
- Reference standard for HPLC, LC-MS, and analytical quality control.
- Cardiovascular studies involving myocardial contractility and vasodilation.
- In vitro and in vivo assays on cardiac and smooth muscle tissues.
- Toxicological and drug interaction research.
- Education and pharmaceutical development studies.
Safety and Handling
Hazard Classification: Toxic
Hazard Statements:
- Toxic if swallowed, inhaled, or absorbed through skin.
- Causes damage to organs through prolonged or repeated exposure.
Precautions:
- Use gloves, protective eyewear, and laboratory coat.
- Handle only in a chemical fume hood.
- Avoid contact with skin, eyes, and clothing.
- Dispose of waste according to local hazardous chemical regulations.
Storage:
- Store refrigerated (2–8 °C) in a tightly closed container.
- Protect from moisture and light.
Packaging and Ordering Information
| Catalog Number | Packaging Type | Pack Size | Container |
|---|---|---|---|
| BIV1326-5G | Bottle | 5 g | Amber glass bottle |
| BIV1326-25G | Bottle | 25 g | Amber glass bottle |
Apollo Scientific Verapamil Hydrochloride is a toxic, high-purity calcium channel blocker widely used in pharmacological, biochemical, and analytical research. It serves as a reliable reference compound for cardiovascular drug studies, receptor binding assays, and quality control in pharmaceutical analysis, ensuring precision and reproducibility in laboratory results.
- Pack Size: 5g 25g
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