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Abcam Anti-SARS-CoV-2 envelope protein antibody, 100µg
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Specifications:
| Application | ELISA-Based Assays, Immunohistochemistry | ||
| Storage Temperature | -20°C | ||
| Product Type | Primary Antibodies | Forms | Liquid |
| Product Brand | abcam | ||
| Product Grade | Molecular Biology | ||
The Abcam Anti-SARS-CoV-2 Envelope Protein Antibody (ab272503) is a rabbit polyclonal IgG antibody raised against the envelope (E) protein of SARS-CoV-2, a critical structural protein involved in viral assembly, budding, and pathogenicity. This antibody is affinity-purified and validated for use in immunohistochemistry on paraffin-embedded tissues (IHC-P) and ELISA, making it a valuable tool for COVID-19 research, virology studies, and immunopathology investigations.
The SARS-CoV-2 envelope protein is a small membrane protein (~8.4 kDa) that functions as a viroporin, forming ion channels that modulate the intracellular ionic environment necessary for efficient viral replication. Its localization in the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) highlights its central role in viral morphogenesis and release. Due to these functions, the envelope protein is increasingly recognized as a key target for antiviral research and therapeutic development.
Key Features
- Rabbit polyclonal antibody targeting SARS-CoV-2 envelope (E) protein
- Detects a highly conserved coronavirus structural protein
- Suitable for IHC-P and ELISA applications
- Affinity-purified for improved specificity
- Validated against SARS-CoV-2 samples
- Supported by peer-reviewed publications
Applications
Validated for use in:
- Immunohistochemistry (IHC-P) on formalin- or PFA-fixed paraffin-embedded tissues
- ELISA for detection of SARS-CoV-2 envelope protein
Common research uses include:
- SARS-CoV-2 tissue localization studies
- Viral assembly and morphogenesis research
- Host–virus interaction studies
- COVID-19 pathogenesis and inflammatory response research
Biological Significance
The SARS-CoV-2 envelope protein:
- Acts as a viroporin, forming ion channels in host membranes
- Plays a central role in virus assembly and budding
- Interacts with other viral structural proteins, including membrane (M) protein
- Modulates host immune responses, including NLRP3 inflammasome activation
- Contributes to epithelial barrier disruption and inflammatory amplification
These properties make the envelope protein an important marker for studying viral replication, immune evasion, and COVID-19-associated pathology.
Antibody Characteristics
| Parameter | Description |
|---|---|
| Catalog Number | ab272503 |
| Host Species | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | SARS-CoV-2 |
| Carrier Free | No |
| Concentration | ~1 mg/mL (batch dependent) |
| Form | Liquid |
| Purification | Affinity purification (immunogen) |
Storage & Handling
- Storage Buffer: PBS, pH 7.2, with 0.02% sodium azide
- Shipping Conditions: Blue ice
- Short-term Storage: +4 °C (1–2 weeks)
- Long-term Storage: −20 °C
- Handling Recommendation: Aliquot upon receipt and avoid repeated freeze–thaw cycles
The Abcam Anti-SARS-CoV-2 Envelope Protein Antibody (ab272503) is a reliable and well-validated research antibody for detecting the coronavirus envelope protein in tissue and immunoassay applications. Its relevance to viral assembly, immune modulation, and COVID-19 pathogenesis makes it a powerful tool for virology, immunology, and infectious disease research.