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VWR® Trifluoroacetic Acid (TFA) ≥99.9% – HiPerSolv CHROMANORM® for LC-MS
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Specifications:
| Application | Analytical Chemistry, chromatography | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Liquid |
| Product Brand | VWR | ||
| Product Grade | LC-MS Grade | Formula | C₂HF₃O₂ |
VWR® Trifluoroacetic Acid (TFA), HiPerSolv CHROMANORM® grade, is an ultra-high purity reagent specifically designed for LC-MS and HPLC applications, where low background noise, high volatility, and exceptional purity are critical.
With an assay of ≥99.9% and extremely low levels of impurities (trace metals, water, and residues), this reagent ensures maximum sensitivity and reproducibility in analytical workflows such as peptide, protein, and small molecule analysis.
Manufactured under the HiPerSolv CHROMANORM® quality standard by Avantor, this TFA is optimized for mass spectrometry compatibility and chromatographic performance.
Key Features & Benefits
1. LC-MS Ultra-High Purity Grade
- ≥99.9% purity with minimal evaporation residue (≤0.0001%)
- Designed for low background interference in MS detection
- Passes stringent LC-MS suitability tests
2. Ideal Ion-Pairing Reagent
- Enhances retention and separation of peptides and polar analytes
- Widely used in reverse-phase HPLC and LC-MS methods
3. Exceptional Trace Metal Control
-
Ultra-low metal content:
- Ca ≤0.2 ppm
- K ≤0.2 ppm
- Mg ≤0.2 ppm
- Na ≤0.5 ppm
- Ensures high reproducibility and minimal signal suppression
4. Excellent Optical Purity
- High UV transmittance across key wavelengths (205–255 nm)
- Suitable for UV and diode-array detection systems
5. Packaged for Stability
- Supplied under nitrogen atmosphere to prevent degradation
- Maintains chemical integrity and shelf stability
Applications
- LC-MS analysis of peptides, proteins, and metabolites
- HPLC mobile phase preparation
- Ion-pair chromatography
- Proteomics and biopharmaceutical analysis
- Analytical method development and validation
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Trifluoroacetic Acid (TFA) |
| Grade | HiPerSolv CHROMANORM® (LC-MS Grade) |
| Purity | ≥99.9% |
| Formula | C₂HF₃O₂ |
| Molecular Weight | 114.02 g/mol |
| CAS Number | 76-05-1 |
| Boiling Point | 71.8 °C |
| Melting Point | -15 °C |
| Density | 1.490 g/cm³ (20 °C) |
| Water Content | ≤0.005% |
| Evaporation Residue | ≤0.0001% |
| Technique Compatibility | LC-MS, HPLC |
| Storage Temperature | Ambient |
| Packaging | Nitrogen-filled glass bottles |
Ordering Information
| Product Code | Pack Size | Packaging |
|---|---|---|
| 84868.180 | 100 mL | Glass bottle |
| 84868.260 | 500 mL | Glass bottle |
| 84868.290 | 1 L | Glass bottle |
Hazard Information
⚠️ Classification: Corrosive, Irritant
- UN Number: 2699
- ADR Class: 8 (Corrosive substances)
Handle with appropriate PPE and laboratory safety protocols.
Analytical Significance
Trifluoroacetic acid is widely used as:
- A mobile phase modifier to improve peak shape
- An ion-pairing agent for enhanced analyte retention
- A volatile acid compatible with mass spectrometry
Its volatility ensures:
- Minimal residue in MS systems
- Improved signal clarity and sensitivity
Unique Advantages
- Ultra-low impurities for high-sensitivity LC-MS analysis
- Excellent UV transparency and chromatographic performance
- Stable packaging under nitrogen atmosphere
- Reliable performance in proteomics and pharmaceutical workflows
- Trusted HiPerSolv CHROMANORM® quality standard
VWR® Trifluoroacetic Acid ≥99.9% (HiPerSolv CHROMANORM®) is a premium-grade reagent designed for demanding LC-MS and HPLC applications. Its exceptional purity, low impurity profile, and optimized performance make it an essential component for laboratories requiring high accuracy, sensitivity, and reproducibility in analytical workflows.
- Pack Size: 100 mL 500 mL 1 Liter