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Specifications:
| Application | cell Signalling | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₃H₁₆N₂O₂ |
Thermo Scientific™ Melatonin (≥99%) is a neurohormone naturally produced by the pineal gland, regulating sleep-wake cycles, circadian rhythms, and stress responses.
In research settings, it is utilized for its antioxidant, neuroprotective, anti-inflammatory, and anti-apoptotic properties. Melatonin also functions as an inhibitor of neuronal nitric oxide synthase (nNOS) and an activator of melatonin receptors MEL-1A-R and MEL-1B-R.
This compound exhibits endogenous antioxidant and immunomodulatory activity, making it valuable in studies of aging, oxidative stress, cancer, and neurodegenerative disorders.
Key Features
- High Purity: >99% (HPLC) for reproducible biological performance.
- Biologically Active Hormone: Regulates circadian rhythm and sleep-wake cycles.
- Antioxidant and Anti-Apoptotic: Upregulates antioxidant enzymes, inhibits nNOS, and protects against oxidative stress.
- Receptor Modulator: Activates melatonin receptors MEL-1A-R and MEL-1B-R.
- Dual Role: Inhibits apoptosis in immune and neural cells while inducing apoptosis in certain cancer cells.
- Light-Sensitive: Store protected from light, in a tightly sealed container.
- Research Use Only (RUO): Not for human or veterinary use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide |
| Synonyms | Melatonine, pineal hormone, MEL, N-acetyl-5-methoxytryptamine |
| CAS Number | 73-31-4 |
| Molecular Formula | C₁₃H₁₆N₂O₂ |
| Molecular Weight | 232.28 g/mol |
| InChI Key | DRLFMBDRBRZALE-UHFFFAOYSA-N |
| SMILES | COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | >99.0% |
| Form | Solid |
| Color | White to off-white crystalline powder |
| Solubility | Soluble in ethanol, DMSO, and methanol |
| Storage Conditions | Cool, dry, light-protected place |
| Packaging | Glass bottle |
| Stability | Light-sensitive |
| Intended Use | Research Use Only (RUO) |
Applications
- Neurobiology: Study of circadian rhythm regulation and sleep-wake mechanisms.
- Pharmacology: Investigations on receptor binding (MEL-1A-R and MEL-1B-R).
- Oncology: Modulation of apoptosis and metastasis inhibition in breast cancer cells.
- Oxidative Stress Research: Regulation of antioxidant enzymes and ROS scavenging.
- Aging and Immunology: Research on neuroprotection and immune cell regulation.
- Endocrinology: Study of hormonal control in stress and circadian signaling.
References
- Borin, T.F. et al. “Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1.” J. Pineal Res. (2016) 60(1), 3–15.
- Tan, D.X. et al. “Melatonin: A hormone, tissue factor, and antioxidant vitamin.” J. Pineal Res. (2003) 34(1), 75–78.
- Dubocovich, M.L. et al. “Pharmacology and function of melatonin receptors.” FASEB J. (1988) 2(12), 2765–73.
- Reiter, R.J. et al. “Mechanisms for the protective actions of melatonin in the CNS.” Ann. N.Y. Acad. Sci. (2001) 939, 200–15.
Safety & Handling
- Signal Word: Danger
-
Hazard Statements:
- H301 – Toxic if swallowed
- H341 – Suspected of causing genetic defects
-
Precautionary Statements:
- P201 – Obtain special instructions before use
- P280 – Wear protective gloves and eye protection
- P301 + P330 + P331 – IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
- P308 + P313 – If exposed, get medical advice
- Classification: Acute Oral Toxicity Cat. 3 | Germ Cell Mutagenicity Cat. 2
The Thermo Scientific™ Melatonin (≥99%) is a research-grade neurohormone essential for studies of circadian rhythm, oxidative stress, apoptosis, and receptor-mediated signaling.
Its high purity, broad biological activity, and reliable Thermo Scientific quality make it ideal for neurobiology, pharmacology, oncology, and endocrinology research.
- Pack Size: 250mg 1g 5g 25g