0
Thermo Scientific™ Ellagic Acid Hydrate, 97% (may contain up to 12% water)
Catalog No :
CAS Number :
Brand :
In Stock
Specifications:
| Application | Analytical Chemistry | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₄H₆O₈ |
Thermo Scientific™ Ellagic Acid Hydrate (≥97%) is a naturally occurring polyphenolic compound found in fruits and nuts, widely recognized for its antioxidant, antitumor, and enzyme-inhibitory properties.
It acts as a selective ATP-competitive inhibitor of casein kinase 2 (CK2), and also inhibits topoisomerases I and II, FGR, GSK, and PKA. Ellagic acid is frequently used in biochemical assays, cancer research, coagulation studies, and enzyme activity investigations.
This reagent-grade compound is air- and light-sensitive, requiring storage under dry inert gas and protection from moisture and light to preserve stability.
Key Features
- High Purity: ≥96.0% (Silylated GC) with ≤12.0% water (Karl Fischer).
- Multifunctional Bioactive Compound: Exhibits antioxidant, antitumor, and kinase inhibition properties.
- Selective CK2 Inhibitor: Blocks casein kinase 2 through ATP-competitive binding.
- Enzyme Inhibition Spectrum: Inhibits glutathione S-transferase, topoisomerase I/II, PKA, and GSK.
- Common Polyphenol: Suitable for analytical and biochemical studies on oxidative stress, cancer, and coagulation.
- Air- and Light-Sensitive: Store under inert atmosphere, away from light and moisture.
- Research Use Only (RUO): For laboratory applications; not for diagnostic or therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0⁴,¹⁶.0¹¹,¹⁵]hexadeca-1(15),4(16),5,7,11,13-hexaene-3,10-dione |
| Synonyms | Ellagic acid, gallogen, benzoaric acid, ellagate, ellagic acid hydrate |
| CAS Number | 476-66-4 |
| Molecular Formula | C₁₄H₆O₈ |
| Molecular Weight | 302.19 g/mol |
| InChI Key | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
| SMILES | OC1=CC2=C3C(OC(=O)C4=CC(O)=C(O)C(OC2=O)=C34)=C1O |
| MDL Number | MFCD00006914 |
Specifications
| Parameter | Specification |
|---|---|
| Purity (Silylated GC) | ≥96.0% |
| Water Content (KF) | ≤12.0% |
| Form | Powder |
| Appearance | White to cream, yellow, green, or brown powder |
| Identification (FTIR) | Conforms |
| Comment | May contain up to 12% water |
| Solubility | Slightly soluble in water; soluble in 1M NaOH, ethanol, and pyridine |
| Storage Conditions | Store in dark, cool, dry conditions under inert gas |
| Stability | Air and light sensitive |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer and pharmacological research: Inhibits CK2 and topoisomerase enzymes.
- Antioxidant and redox biology: Studies on free radical scavenging and cellular defense mechanisms.
- Coagulation and hematology research: Factor XIIa assay and plasma activation studies.
- Enzyme inhibition assays: Investigations on FGR, GSK, and protein kinase A pathways.
- Drug discovery: Structural analog in anticancer and anti-inflammatory compound screening.
- Neuroscience and immunology: Exploration of polyphenol-mediated signal modulation.
References
- Soh, P.N. et al., “In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment.” Antimicrob. Agents Chemother. (2009) 53(7), 3060–3066.
- Kim, S. et al., “Thermosensitive Gel Delivery of Ellagic Acid for Brain Cancer Therapy.” Biomaterials (2010) 31(14), 4157–4166.
Safety & Handling
- Signal Word: Warning
-
Hazard Statements:
- H315 – Causes skin irritation
- H319 – Causes serious eye irritation
- H335 – May cause respiratory irritation
- Precautions: P280, P302+P352, P304+P340, P312, P332+P313, P337+P313
- Classification: Skin Irritation Cat. 2 | Eye Irritation Cat. 2 | STOT (Single Exposure) Cat. 3
The Thermo Scientific™ Ellagic Acid Hydrate (≥97%) is a research-grade polyphenol inhibitor known for its antitumor, antioxidant, and enzyme inhibition properties.
With broad applicability in biochemical, pharmacological, and cancer research, it offers high purity, consistent quality, and reproducible results, meeting Thermo Scientific’s standards for advanced laboratory reagents.
- Pack Size: 100g 5g 25g