Thermo Scientific™ Dicyclohexylcarbodiimide (DCC), ≥99%

Thermo Scientific™ Dicyclohexylcarbodiimide (DCC), ≥99% is a high-purity carbodiimide reagent widely used as a coupling agent for amide and ester bond formation in organic synthesis. It is a cornerstone reagent in peptide synthesis, pharmaceutical development, and advanced chemical research, enabling efficient activation of carboxylic acids for condensation reactions.

DCC facilitates the formation of peptide bonds by converting carboxylic acids into reactive intermediates, allowing nucleophilic attack by amines or alcohols. Its reliability and high purity make it a preferred reagent for solution-phase and solid-phase synthesis workflows.

Key Features

• High Purity (≥99%)
  Ensures reproducible and high-yield coupling reactions.
• Efficient Coupling Reagent
  Promotes rapid formation of amide and ester bonds.
• Widely Used in Peptide Synthesis
  Ideal for both small-scale and preparative applications.
• Versatile Organic Reagent
  Applicable in a broad range of synthetic and research workflows.
• Consistent Analytical Quality
  Suitable for pharmaceutical and fine chemical applications.

Applications

Peptide & Protein Chemistry

• Peptide bond formation
• Solid-phase and solution-phase peptide synthesis
• Protein conjugation and modification

Organic Synthesis

• Amide formation from carboxylic acids and amines
• Esterification reactions
• Dehydration and condensation reactions

Pharmaceutical & Chemical Research

• Synthesis of active pharmaceutical ingredients (APIs)
• Medicinal chemistry research
• Fine chemical and intermediate production

Polymer & Materials Science

• Polymer crosslinking and functionalization
• Preparation of specialty materials

Reaction Principle

DCC activates carboxylic acids to form a reactive O-acylisourea intermediate, which reacts with nucleophiles (amines or alcohols) to form:

• Amides (peptide bonds)
• Esters

The reaction produces dicyclohexylurea (DCU) as a byproduct, which is typically insoluble and easily removed by filtration.

Chemical Information

Physical Properties

Safety & Handling

• Hazard Classification: Toxic, Corrosive, Irritant (UN 2811, ADR Class 6.1, III)
• Handling: Use in a fume hood with appropriate PPE
• Storage: Store in a tightly sealed container at ambient temperature
• Precautions: Avoid contact with skin and eyes; handle with care due to sensitization risk

Ordering Information

Unique Advantages

• Highly Efficient Coupling Performance
  Enables rapid and high-yield bond formation in synthetic chemistry.
• Widely Accepted Standard Reagent
  Trusted in peptide synthesis and organic chemistry workflows.
• Easy Byproduct Removal
  Insoluble DCU simplifies purification processes.
• Broad Application Range
  Suitable for pharmaceuticals, polymers, and advanced materials research.

Thermo Scientific™ Dicyclohexylcarbodiimide (DCC), ≥99% is a reliable and high-performance coupling reagent essential for amide and ester bond formation. Its high purity, versatility, and proven effectiveness make it a key reagent for laboratories engaged in peptide synthesis, pharmaceutical development, and advanced organic chemistry.