0
Specifications:
| Application | pharmaceutical, Organic Synthesis | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₄H₁₀Cl₂NNaO₂ |
NSAID and Dual Cyclooxygenase (COX) Inhibitor – COX-1 & COX-2
Diclofenac Sodium Salt is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent dual inhibitor of COX-1 and COX-2 enzymes. This compound is commonly used in inflammation and pain research, especially for investigating prostaglandin synthesis pathways, cytochrome P450 metabolism, and amyloid diseases involving transthyretin (TTR) stabilization.
Key Features & Benefits
- Dual COX inhibitor: Inhibits both COX-1 and COX-2, reducing prostaglandin E2 synthesis and associated inflammation
- Research grade (RUO): Ideal for preclinical studies and biochemical assays
- High purity (≥97.5%): Ensures consistency in experimental results
- Stable TTR modulator: Shown to stabilize the native tetrameric form of transthyretin, helping prevent amyloid fibril formation
- CYP2C9 substrate: Useful in drug metabolism and pharmacokinetics (DMPK) research
Applications
- Anti-inflammatory and analgesic research
- COX enzyme inhibition studies
- Prostaglandin biosynthesis pathway modulation
- Transthyretin (TTR) fibril inhibition in amyloidosis models
- Drug–enzyme interaction assays (CYP2C9 studies)
- Pharmacological and biochemical pathway characterization
Solubility Profile
| Solvent | Solubility |
|---|---|
| Water | 50 mg/mL |
| PBS (pH 7.2) | 6 mg/mL |
| Ethanol | ~35 mg/mL |
| DMSO / DMF | ~35 mg/mL |
| Methanol | >24 mg/mL |
| Acetone | 6 mg/mL |
Specifications
| Attribute | Description |
|---|---|
| Catalog Numbers | J62609.06 (5 g), J62609.14 (25 g), J62609.22 (100 g) |
| CAS Number | 15307-79-6 |
| Molecular Formula | C14H10Cl2NO2.Na |
| Form | Powder |
| Appearance | White |
| Purity | ≥97.5% (from CoA) |
| Storage Conditions | Store in a cool, dry, ventilated place |
| Product Use | Research Use Only (RUO) |
Safety & Handling
- Avoid exposure to strong oxidizing agents
- Use in a well-ventilated lab with appropriate PPE
- Refer to MSDS for full handling and hazard information
Ordering Information
| Product Description | Catalog No. | Quantity | |
|---|---|---|---|
| Diclofenac Sodium Salt – Powder | J62609.06 | 5 g | |
| Diclofenac Sodium Salt – Powder | J62609.14 | 25 g | |
| Diclofenac Sodium Salt – Powder | J62609.22 | 100 g |
Thermo Scientific™ Diclofenac Sodium Salt is a versatile, well-characterized research chemical ideal for pain, inflammation, and neurodegenerative disease studies. With dual COX inhibition, high solubility, and proven relevance in both enzymology and amyloid research, it serves as a reliable tool for pharmaceutical and academic investigations into NSAID mechanisms, TTR modulation, and CYP450 metabolism.
- Pack Size: 100g 5g 25g