0
Thermo Scientific™ Dextromethorphan hydrobromide
Catalog No :
CAS Number :
Brand :
In Stock
Specifications:
| Application | HPLC | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₈H₂₆BrNO |
NMDA Receptor Ligand and Central Nervous System Antitussive Agent
Dextromethorphan Hydrobromide is a crystalline powder commonly used as a centrally acting antitussive (cough suppressant) and NMDA receptor ligand in neuroscience, pharmacology, and pharmaceutical research. This compound is a widely known active pharmaceutical ingredient (API) in over-the-counter (OTC) cold medications and is also studied for its potential roles in analgesia, neuroprotection, and behavioral modulation.
This research-grade material is manufactured under high-purity specifications (≥98%), making it suitable for a variety of non-clinical laboratory applications.
Key Features & Benefits
-
High Assay Purity (≥98%, HPLC)
Ensures batch-to-batch consistency for analytical and formulation research. -
Well-characterized CNS-active compound
Widely used in studies involving cough suppression, NMDA receptor modulation, and central nervous system pharmacology. -
Reliable physical properties
Optical rotation of +27° to +30° and pH 5.2–6.5 in aqueous solution. -
Highly soluble
Soluble in water (40 mM) and alcohol (1:10), facilitating ease of use in various assay systems.
Applications
- Antitussive research (non-opioid cough suppression models)
- NMDA receptor agonist/antagonist studies
- Pain modulation and central sensitization models
- Pharmaceutical excipient/formulation compatibility testing
- Pharmacokinetics and metabolite profiling (e.g., dextrorphan studies)
- In vitro screening of neuroactive or psychotropic compounds
For Research Use Only. Not for use in diagnostic or therapeutic applications.
Chemical & Physical Properties
| Attribute | Value |
|---|---|
| CAS Number | 125-69-9 |
| Chemical Name | Dextromethorphan Hydrobromide |
| Molecular Formula | C₁₈H₂₆BrNO |
| Molecular Weight | 352.32 g/mol |
| Form | Crystalline powder |
| Appearance | White |
| Optical Rotation | +27° to +30° (c = 1.5 in H₂O) |
| pH (1% solution) | 5.2 – 6.5 |
| Water Content | 3.5–5.5% (Karl Fischer) |
Solubility
| Solvent | Solubility |
|---|---|
| Water | ~40 mM |
| Alcohol | Soluble at ~1:10 ratio |
Ordering Information
| Product Description | Catalog No. | Quantity |
|---|---|---|
| Dextromethorphan Hydrobromide – 5 g | J61732.06 | 5 g |
| Dextromethorphan Hydrobromide – 10 g | J61732.09 | 10 g |
| Dextromethorphan Hydrobromide – 50 g | J61732.18 | 50 g |
Storage & Handling
- Storage: Store in a cool, dry, well-ventilated place
- Precautions: Avoid strong oxidizing agents
- Shelf Life: Refer to the Certificate of Analysis
- Regulatory Note: RUO – For Research Use Only
Thermo Scientific™ Dextromethorphan Hydrobromide is a versatile, CNS-active compound widely used in neuroscience and pharmaceutical research. With its well-characterized pharmacological profile, high purity, and excellent solubility, it serves as a trusted reagent for cough suppression, NMDA modulation, and neurobehavioral studies in both academic and industrial laboratories.
- Pack Size: 5g 10g 50g