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Thermo Scientific™ Carboplatin (HPLC) 98.0%
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Specifications:
| Application | Cell Analysis, Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₆H₁₂N₂O₄Pt |
Thermo Scientific™ Carboplatin is a platinum-based antineoplastic compound widely used in oncology and biochemical research. It belongs to the class of DNA cross-linking agents that interfere with DNA replication and repair, leading to apoptosis in rapidly dividing cells.
Carboplatin serves as a research-grade cytotoxic reagent and a model compound for studying platinum coordination chemistry, drug–DNA interactions, and the mechanism of action of platinum-based chemotherapeutics.
Key Features
- High Purity: ≥98.0% by HPLC.
- Platinum-based Antitumor Agent: Used in research on cancer treatment mechanisms.
- Mode of Action: Forms intra- and inter-strand DNA crosslinks, inhibiting DNA synthesis and replication.
- Solubility: Readily soluble in water for easy preparation of aqueous solutions.
- Research Use: Ideal for studies on platinum coordination chemistry and DNA-binding agents.
- Physical Form: Fine white to off-white crystalline powder.
- Storage: Store in a cool, dry, and well-ventilated area; tightly sealed.
- Research Use Only (RUO): Not for diagnostic or therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | 5,9-dioxo-6,8-dioxa-7-platinaspiro[3.5]nonane-7,7-bis(ylium) diamine |
| Synonyms | Platinum(II) complex, antineoplastic agent |
| CAS Number | 41575-94-4 |
| Molecular Formula | C₆H₁₂N₂O₄Pt |
| Molecular Weight | 371.26 g/mol |
| InChI Key | BHKICZDKIIDMNR-UHFFFAOYSA-L |
| SMILES | N.N.O=C1O[Pt++]OC(=O)C11CCC1 |
| MDL Number | MFCD00070464 |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥98.0% |
| Form | Powder |
| Appearance | White to off-white |
| Solubility | Soluble in water |
| Storage Temperature | Cool, dry place (ambient) |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Investigation of carboplatin’s cytotoxic and DNA-binding mechanisms.
- Molecular Biology: Studies of DNA crosslinking and repair pathways.
- Pharmacology: Model compound for platinum-based drug studies.
- Biochemical Research: Development of novel metal-coordination therapeutic agents.
- Structural Biology: Crystallographic and chemical analysis of platinum–protein complexes.
References
- Jakacki, R.I. et al., “Outcome and Prognostic Factors for Children With Supratentorial Primitive Neuroectodermal Tumors Treated With Carboplatin During Radiotherapy.” Pediatr. Blood Cancer (2015), 62(5), 776–783.
- Boal, A.K. & Rosenzweig, A.C., “Response to Crystallography and Chemistry of Protein Complexes with Cisplatin and Carboplatin.” Acta Crystallogr. Sect. D (2015), 71, 1984–1986.
The Thermo Scientific™ Carboplatin (≥98%) is a high-purity platinum-based compound used as a research-grade antitumor and DNA crosslinking agent.
Valuable in studies of oncology, DNA repair, and coordination chemistry, this reagent offers reliable purity and performance for investigating the molecular mechanisms of platinum-based chemotherapy.
- Pack Size: 1g 5g