Sigma-Aldrich™ Fmoc-Lys(Fmoc)-OH ≥97.5% (HPLC), for peptide synthesis

Fmoc-Lys(Fmoc)-OH, also known as Nα,Nε-Di-Fmoc-L-lysine, is a high-purity, dual-protected lysine derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features Fmoc protection on both the α-amino group and the ε-amino side chain, enabling controlled peptide assembly and making it particularly useful for branched peptide synthesis.

This reagent is widely used in custom peptide synthesis, pharmaceutical research, peptide vaccine development, multivalent peptide design, drug delivery research, protein engineering, and bioorganic chemistry. The dual Fmoc protection strategy allows lysine to serve as a branching point for dendritic, multivalent, or polymeric peptide structures.

Key Features

Chemical Properties & Identifiers

Applications

Fmoc-Lys(Fmoc)-OH is suitable for:

• Fmoc-based solid-phase peptide synthesis
• Incorporation of lysine residues into synthetic peptides
• Branched peptide synthesis
• Dendritic and multivalent peptide design
• Peptide vaccine and antigenic epitope presentation research
• Peptide-based pharmaceutical and drug discovery research
• Protein engineering and structural biology studies
• Peptide modification and functionalized peptide synthesis
• Polymeric peptide conjugates and drug delivery research
• Bioorganic chemistry and peptidomimetic synthesis

Ordering Information

Storage & Handling

Store at 2–30 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.

Research Use Statement

For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.