MCE Streptozotocin (STZ) ≥99.20%

MCE Streptozotocin (Streptozocin; STZ) is a high-purity nitrosourea antibiotic widely used in research for the induction of experimental diabetes models and the study of pancreatic β-cell function.

Streptozotocin selectively enters pancreatic β-cells via the GLUT2 transporter, where it induces DNA alkylation and oxidative stress, leading to β-cell apoptosis. This mechanism makes it a critical tool in diabetes research, metabolic studies, and cytotoxicity investigations.

With well-established applications in both in vitro and in vivo models, Streptozotocin is a standard reagent in biomedical and pharmaceutical research.

Key Features and Benefits

High Purity and Research-Grade Quality

• Purity: ≥99.20%
• Consistent performance for reproducible experimental outcomes

Selective β-Cell Targeting Mechanism

• Transported via GLUT2 into pancreatic β-cells
• Induces DNA methylation and apoptosis

Established Model Induction Tool

• Widely used for Type 1 and Type 2 diabetes models
• Suitable for multiple animal species and experimental protocols

Broad Research Applications

• Used in cytotoxicity, oxidative stress, and mitochondrial dysfunction studies
• Applicable in cancer and metabolic disease research

Flexible Experimental Use

• Compatible with in vitro cell studies and in vivo animal models
• Water-soluble and suitable for rapid preparation

Applications

• Induction of Type 1 diabetes (T1DM) animal models
• Induction of Type 2 diabetes (T2DM) models (with dietary protocols)
• Pancreatic β-cell cytotoxicity studies
• Oxidative stress and mitochondrial dysfunction research
• Cancer and anticancer drug research
• Metabolic disease and endocrinology studies

Mechanism of Action

• Enters β-cells via GLUT2 transporter
• Causes DNA alkylation (DNA methylation)
• Induces oxidative stress and mitochondrial damage
• Leads to β-cell apoptosis and insulin deficiency

Technical Specifications

Available Sizes

Preparation and Handling

• Dissolve in cold acidic citrate buffer (pH 4.0–4.7) before use
• Prepare fresh solutions immediately prior to experiments
• Avoid prolonged exposure to neutral or alkaline conditions
• Protect from light and moisture

Storage and Stability

• Store at -20°C, sealed and protected from light and moisture
• Solutions are unstable; fresh preparation is recommended
• Ship at ambient conditions (may vary by region)

Important Experimental Considerations

• Sensitivity varies across species and strains
• Dosage and administration protocols require optimization through pilot studies
• Post-treatment care (e.g., glucose supplementation) may be required in animal studies
• Avoid repeated freeze-thaw cycles

Safety and Compliance

• For research use only
• Not for therapeutic or diagnostic use
• Handle with appropriate laboratory safety precautions
• Refer to SDS for detailed safety information

Unique Advantages

• Widely validated reagent for diabetes model induction
• High selectivity for pancreatic β-cells
• Reliable and reproducible research outcomes
• Suitable for both in vitro and in vivo studies
• Trusted quality from MCE

MCE Streptozotocin (STZ) ≥99.20% is a critical reagent for researchers studying diabetes, metabolic disorders, and cellular cytotoxicity. Its well-characterized mechanism, high purity, and versatility make it an indispensable tool in modern biomedical research.