MCE Epifriedelanol ≥99.69%

Epifriedelanol (3-epifriedelinol) is a naturally occurring triterpenoid compound isolated from plant sources such as the root bark of Ulmus davidiana. It has attracted significant interest in biochemical and pharmacological research due to its reported antitumor, anti-inflammatory, and anti-senescence properties.

This compound has demonstrated the ability to induce apoptosis in cancer cell lines, including DU145 prostate cancer cells, and may inhibit cellular senescence in human primary cells. Epifriedelanol is therefore widely used in studies investigating cell signaling pathways, apoptosis mechanisms, oxidative stress, and anticancer research.

MedChemExpress Epifriedelanol is supplied at high purity (≥99.69%), making it suitable for cell biology, molecular biology, and pharmacology research applications.

Key Features

• High purity research compound (≥99.69%)
• Natural triterpenoid bioactive molecule
• Demonstrated apoptosis-inducing activity in cancer cell lines
• Reported anti-inflammatory and anti-tumor properties
• Used in cellular senescence and oxidative stress research
• Suitable for in vitro and in vivo experimental studies

Chemical Information

Biological Activity

Epifriedelanol exhibits several biological activities relevant to pharmacological research:

• Induction of apoptosis in DU145 prostate cancer cells
• Antitumor activity demonstrated in in vitro assays
• Anti-inflammatory effects through suppression of inflammatory markers
• Inhibition of cellular senescence in human dermal fibroblasts and endothelial cells
• Regulation of apoptosis-related proteins including p53, p21, BAX, NF-κB, and BCL2

Studies have also shown that epifriedelanol can suppress reactive oxygen species (ROS) production and reduce oxidative stress associated with drug-induced cellular aging.

In Vitro Research Findings

Experimental studies have reported:

• Cytotoxicity testing in cancer cell lines such as MCF7, NCI-H460, SF-268, TK-10, and UACC-62
• Apoptotic activity in DU145 prostate cancer cells with IC₅₀ values around 32–35 μM after 72 hours
• Downregulation of p53 and p21 proteins induced by adriamycin treatment
• Suppression of senescence-associated β-galactosidase activity in primary human cells

In Vivo Research Findings

Animal studies using Sprague-Dawley rats have demonstrated that Epifriedelanol:

• Reduces Bisphenol A (BPA)-induced gonadotoxicity
• Decreases oxidative stress markers
• Suppresses inflammatory mediators including NO, IL-6, and TNF-α
• Maintains physiological estradiol levels
• Shows favorable biosafety without detectable hematological toxicity

Solubility Information

Storage Conditions

• Store at 4 °C, protected from light
• In solvent:
  • −80 °C: stable for up to 6 months
  • −20 °C: stable for up to 1 month

Available Pack Sizes

Epifriedelanol is a biologically active triterpenoid widely used in pharmacological and molecular biology research focusing on apoptosis, cancer cell signaling, oxidative stress, and inflammation pathways. With high purity and well-documented biological activity, MedChemExpress Epifriedelanol provides researchers with a reliable compound for studying mechanisms of cellular senescence, tumor suppression, and inflammatory regulation in both in vitro and in vivo models.