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Specifications:
| Application | Life Science Applications, Biopharmaceutical Research | ||
| Storage Temperature | -20°C | ||
| Product Type | Proteins & Peptides | Forms | Solid |
| Product Brand | MedChem Express | ||
| Product Grade | Analytical grade | Formula | C₂₇H₄₄N₄O₅ |
Dihexa is a synthetic oligopeptide and potent angiotensin IV analog designed for advanced neuroscience and neurodegeneration research. It is distinguished by its oral bioavailability and ability to cross the blood-brain barrier, making it highly valuable in studies targeting central nervous system (CNS) mechanisms.
Dihexa exerts its biological activity through high-affinity binding to hepatocyte growth factor (HGF) (Kd ≈ 65 pM), enhancing HGF signaling via the c-Met receptor pathway. This mechanism has been associated with synaptogenesis, neuroplasticity, and cognitive enhancement in preclinical models.
⚠️ For research use only. Not for human or veterinary use.
Key Features & Benefits
1. High-Affinity HGF Modulator
- Binds HGF with picomolar affinity (Kd = 65 pM)
- Potentiates c-Met receptor activation
- Enhances downstream neurotrophic signaling pathways
2. Blood-Brain Barrier Penetration
- Efficient CNS delivery
- Suitable for in vivo neurological studies
3. Promotes Synaptogenesis & Neuroplasticity
- Induces hippocampal spinogenesis
- Supports synaptic connectivity and repair mechanisms
4. Cognitive Function Enhancement (Preclinical)
- Improves spatial learning and memory in animal models
- Reverses scopolamine-induced cognitive deficits
5. Long Circulating Half-Life
- Sustained biological activity in in vivo systems
- Ideal for extended pharmacological studies
Applications
- Neurodegenerative disease research (e.g., Alzheimer’s disease models)
- Synaptic plasticity and neurogenesis studies
- HGF/c-Met signaling pathway investigations
- Cognitive enhancement and memory research
- Drug discovery targeting CNS disorders
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Dihexa |
| Purity | ≥98.92% |
| Molecular Formula | C₂₇H₄₄N₄O₅ |
| Molecular Weight | 504.66 g/mol |
| CAS Number | 1401708-83-5 |
| Appearance | White to off-white solid |
| Target | HGF (Kd: 65 pM) |
| Solubility | DMSO (up to 100 mg/mL; ultrasonic recommended) |
| Storage (Powder) | -20°C (3 years), 4°C (2 years) |
| Storage (Solution) | -80°C (6 months), -20°C (1 month) |
Ordering Information
| Size | Catalog No. |
|---|---|
| 10 mM × 1 mL (in DMSO) | HY-16969-1ML |
| 2 mg | HY-16969-2MG |
| 5 mg | HY-16969-5MG |
| 10 mg | HY-16969-10MG |
| 25 mg | HY-16969-25MG |
| 50 mg | HY-16969-50MG |
| 100 mg | HY-16969-100MG |
| 1 g | HY-16969-1G |
Mechanism of Action
Dihexa enhances HGF-mediated activation of the c-Met receptor, leading to:
- Increased neuronal growth and differentiation
- Enhanced synaptic density
- Improved signal transduction efficiency in neural circuits
Unlike direct agonists, Dihexa acts as a positive modulator, amplifying endogenous HGF activity even at subthreshold concentrations.
Unique Advantages
- Ultra-high potency (picomolar binding)
- Orally active peptide (rare among neuropeptides)
- BBB permeability – ideal for CNS targeting
- Strong preclinical cognitive enhancement data
- Valuable tool for next-generation neurotherapeutic research
MCE Dihexa is a next-generation neuroactive peptide designed for advanced CNS research, offering a unique combination of BBB permeability, HGF pathway modulation, and synaptogenic activity. Its strong preclinical profile makes it a powerful candidate for investigating neurodegenerative diseases and cognitive function mechanisms.
- Pack Size: 5 mg 25 mg 10 mM x 1 mL in DMSO 50 mg 2 mg 100 mg 1 g 10 mg