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Thermo Scientific™ Methicillin sodium salt, ≥99%, 1g
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Specifications:
| Application | Analysis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₁₇H₁₉N₂NaO₆S |
Thermo Scientific™ Chemicals Methicillin Sodium Salt is a β-lactam antibiotic primarily used in research and microbiological studies involving Gram-positive bacteria, particularly Staphylococcus aureus.
It functions by inhibiting bacterial cell-wall synthesis through irreversible binding to penicillin-binding proteins (PBPs)—enzymes responsible for cross-linking peptidoglycan layers. The loss of cell-wall integrity ultimately leads to cell lysis and bacterial death.
This compound is intended for research use only (RUO) and serves as a reference antibiotic in susceptibility testing, mechanism-of-action studies, and β-lactamase resistance research.
Key Features
- Purity: ≥90.0% (meets analytical quality standards).
- Form: White to off-white powder with ≤10.0% water content.
- High selectivity: Active against Gram-positive organisms, especially S. aureus.
- Mode of action: Inhibits transpeptidase (PBP) enzymes to block peptidoglycan crosslinking in bacterial cell walls.
- Research-grade material: Supplied under the Thermo Scientific™ Chemicals brand (formerly Alfa Aesar).
- Regulatory note: Product supplied for laboratory and research use only, not for therapeutic or diagnostic applications.
Chemical Identifiers
| Property | Value |
|---|---|
| CAS Number | 132-92-3 |
| IUPAC Name | Sodium (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carSodium (2S,5R,6R)-6-(2,6-dimethoxybenzamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Molecular Formula | C₁₇H₁₉N₂NaO₆S |
| Molecular Weight | 402.40 g/mol |
| InChI Key | MGFZNWDWOKASQZ-UMLIZJHQSA-M |
| SMILES | [Na+].COC1=CC=CC(OC)=C1C(=O)N[C@H]1[C@H]2SC(C)(C)C@@HC([O-])=O |
| Synonyms | Methicillin sodium; Methicillin sodium anhydrous; Meticillin sodium salt; Dimocillin sodium |
| Storage Conditions | Store at 2–8 °C, in tightly closed container |
| Safety Classification | Research Use Only (RUO) |
Specifications
| Parameter | Specification |
|---|---|
| Form | Powder |
| Appearance | White to off-white |
| Purity | ≥90.0% |
| Water Content | ≤10.0% |
| Solubility | Soluble in water |
| Stability | Inactivated by gastric acid; suitable for in vitro applications |
| Packaging | 1 g vial |
| Compliance | REACH compliant; subject to internal regulatory documentation if required |
Applications
-
Microbiological Research:
Used in in vitro studies on methicillin-susceptible and -resistant S. aureus (MSSA/MRSA). -
Mechanism of Action Studies:
Investigates inhibition of cell wall biosynthesis and β-lactamase enzyme activity. -
Pharmaceutical Development:
Serves as a control compound for β-lactam antibiotic screening. -
Biochemical Assays:
Reference compound for penicillin-binding protein (PBP) interaction studies.
References
- Campanella, L. et al. Journal of Pharmaceutical and Biomedical Analysis (1988) 6(3), 299–305.
- Schwartz, M.A. & Tutt, D.E. J. Am. Chem. Soc. (1971) 93(3), 767–772.
The Thermo Scientific™ Chemicals Methicillin Sodium Salt (≥90%) is a research-grade antibiotic standard designed for microbiological and biochemical investigations into bacterial cell-wall synthesis inhibition and antibiotic resistance.
Produced under stringent quality standards, it provides consistent purity and performance for laboratories studying β-lactam mechanisms, MRSA resistance, and PBP enzymology.