Apollo Sci. Di-tert-butylsilyl-bis(trifluoromethanesulphonate)

Apollo Scientific Di-tert-butylsilyl-bis(trifluoromethanesulphonate), commonly referred to as Di-tert-butylsilyl ditriflate, is a highly reactive organosilicon reagent widely used in advanced organic synthesis. This powerful silylating and activating agent is particularly valuable in selective protection strategies and in the activation of alcohols and carbonyl compounds.

Due to its strong electrophilic character and triflate leaving groups, it is frequently employed in complex molecule construction and specialty chemical synthesis.

⚠ Hazard Classification: Corrosive

⚠ UN 3265 | ADR Class 8, II

Chemical Information

• Synonyms:
  • Di-tert-butylsilyl Ditriflate
  • Di-tert-butylbis(trifluoromethanesulphonyloxy)silane
• CAS Number: 85272-31-7
• Molecular Formula: C₁₀H₁₈F₆O₆S₂Si
• Molecular Weight: 440.44 g/mol

Physical & Chemical Properties

• Appearance: Typically colorless to pale yellow liquid
• Boiling Point: 263 °C
• Density: 1.36 g/cm³ (25 °C)
• Flash Point: 91 °C
• Storage Temperature: Ambient (protect from moisture)

Applications

• Selective silylation reactions
• Protection of diols and alcohols
• Activation of hydroxyl groups
• Glycosylation chemistry
• Complex molecule synthesis
• Pharmaceutical intermediate preparation
• Organosilicon chemistry research

Advantages

• Strong triflate leaving groups
• High reactivity toward nucleophiles
• Efficient diol protection
• Useful in moisture-sensitive transformations
• Valuable reagent in multi-step synthetic routes

Available Pack Sizes

Safety & Handling

• Corrosive material — handle with extreme care
• Use under inert atmosphere where required
• Avoid contact with moisture
• Use appropriate PPE (gloves, goggles, lab coat)
• Refer to SDS before use

Apollo Scientific Di-tert-butylsilyl-bis(trifluoromethanesulphonate) is a high-performance silylating and activating reagent essential for advanced organic synthesis and pharmaceutical research. Its strong electrophilic nature and efficient leaving groups make it a valuable tool in complex molecule construction.

Ideal for research laboratories engaged in organosilicon chemistry, protective group strategies, and specialty synthesis.