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Thermo Scientific™ N-Fmoc-L-serine, 97+%, ≥97.0% (HPLC, U.S. Specification)
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Specifications:
| Application | Protein Biology, Peptide Synthesis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Amino Acid & Biochemicals | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™ | ||
| Product Grade | Analytical grade | Formula | C₁₈H₁₇NO₅ |
N-Fmoc-L-Serine is a high-purity, Fmoc-protected serine derivative used in solid-phase peptide synthesis (SPPS), biochemical research, proteomics, medicinal chemistry, and pharmaceutical development. It features an Fmoc-protected α-amino group, enabling controlled deprotection and stepwise peptide elongation during peptide synthesis.
Serine contains a hydroxyl side chain, making it valuable for the synthesis of hydrophilic peptides and for research involving post-synthetic modification, phosphorylation studies, glycopeptide synthesis, enzyme-substrate interactions, and protein engineering.
Key Features
| Feature | Details |
|---|---|
| High Purity | 97+% grade for reliable peptide synthesis performance |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| High Enantiomeric Purity | ≥99.0% enantiomeric excess for strong chiral integrity |
| Hydroxyl Side Chain | Supports functionalization, phosphorylation, and glycopeptide-related studies |
| Analytical Validation | Characterized by HPLC, FTIR, proton NMR, and Karl Fischer titration |
| Versatile Research Use | Suitable for peptide synthesis, proteomics, drug discovery, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | N-Fmoc-L-Serine, 97+% |
| CAS Number | 73724-45-5 |
| Empirical Formula | C₁₈H₁₇NO₅ |
| Molecular Weight | 327.34 g/mol |
| Form | Powder |
| Appearance | White |
| Optical Rotation | -10° to -11.5°; c = 1 in DMF, U.S. specification |
| Optical Rotation, Non-U.S. | +13 ± 2°; c = 1 in ethyl acetate |
| Enantiomeric Excess | ≥99.0% |
| Assay | ≥97.0% by HPLC, U.S. specification |
| Water Content | ≤6.0% by Karl Fischer titration |
| Identification | FTIR and proton NMR conform to structure |
| Functional Groups | Fmoc, amine, hydroxyl, carboxylic acid |
Applications
N-Fmoc-L-Serine is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of serine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Proteomics and biochemical research
- Protein engineering and structural biology studies
- Enzyme-substrate and inhibitor studies
- Hydrophilic peptide synthesis
- Glycopeptide and phosphorylation-related research
- Bioorganic chemistry and functionalized peptide synthesis
Ordering Information
| Catalog Number | Quantity |
|---|---|
| B21079.03 | 1 g |
| B21079.06 | 5 g |
Storage & Handling
Store in a cool, dry place in a tightly sealed container. Protect from moisture, light, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
- Pack Size: 1g 5g