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Specifications:
| Application | Analytical Chemistry | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₄H₆O₈ |
Thermo Scientific™ Ellagic Acid (≥97%) is a naturally occurring polyphenolic compound widely used in biochemical, pharmacological, and analytical research.
It functions as a selective ATP-competitive inhibitor of casein kinase 2 (CK2) and demonstrates antitumor, antioxidant, and enzyme inhibitory activity.
Ellagic acid also inhibits glutathione S-transferase (GST) and acts as a DNA topoisomerase I/II, FGR, GSK, and PKA inhibitor, making it a valuable tool for signal transduction and cancer biology studies.
This compound is air- and light-sensitive and should be stored under inert, dry conditions.
Key Features
- High Purity: 96.0–104.0% (TBAH titration) ensuring reproducible results in biochemical assays.
- Biologically Active: Inhibits CK2, GST, and protein kinases involved in tumor progression.
- Versatile Use: Applied in studies on antioxidant mechanisms, apoptosis, and coagulation factors.
- Research Grade: Ideal for cancer, enzymology, and malaria drug development research.
- Physical Form: Beige to green powder with conforming IR spectrum.
- Storage: Air- and light-sensitive; store under inert gas in a cool, dark, dry place.
- Research Use Only (RUO): Not intended for human or animal therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0⁴,¹⁶.0¹¹,¹⁵]hexadeca-1(15),4(16),5,7,11,13-hexaene-3,10-dione |
| Synonyms | Ellagic acid, Gallogen, Benzoaric acid, Ellagate |
| CAS Number | 476-66-4 |
| Molecular Formula | C₁₄H₆O₈ |
| Molecular Weight | 302.19 g/mol |
| InChI Key | AFSDNFLWKVMVRB-UHFFFAOYSA-N |
| SMILES | OC1=CC2=C3C(OC(=O)C4=CC(O)=C(O)C(OC2=O)=C34)=C1O |
| MDL Number | MFCD00006914 |
Specifications
| Parameter | Specification |
|---|---|
| Purity | 97% minimum (96–104% TBAH titration) |
| Form | Powder |
| Color | Beige to green |
| Infrared Spectrum | Conforms |
| Solubility | Slightly soluble in water; soluble in 1 M NaOH, ethanol, and pyridine |
| Storage Conditions | Dry, inert atmosphere; protect from air and light |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Enzyme Inhibition: Inhibitor of CK2, GST, Topo I/II, PKA, and GSK kinases.
- Cancer Research: Exhibits antitumor and pro-apoptotic activity in cell-based assays.
- Antioxidant Studies: Evaluates redox and free radical scavenging activity.
- Coagulation Research: Used for factor XIIa assays and studies on contact activation in plasma.
- Drug Development: Investigated for malaria and brain cancer treatment models.
- Nanomedicine: Formulation of chitosan or β-glycerophosphate gels for controlled delivery.
References
- Soh, P.N. et al. “In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment.” Antimicrob. Agents Chemother. (2009) 31100–1106.
- Kim, S. et al. “Thermo-sensitive Gel Delivery of Ellagic Acid for Brain Cancer.” Biomaterials (2010) 31(14), 4157–4166.
The Thermo Scientific™ Ellagic Acid (97%) is a high-purity bioactive polyphenol with broad biochemical and pharmacological relevance.
Recognized for its antioxidant, antitumor, and enzyme-inhibitory properties, it is widely used in cell signaling, oncology, malaria, and coagulation research.
- Pack Size: 50g 10 Grams 2.5g