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Specifications:
| Application | cell Signalling, Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₄₃H₅₃NO₁₄ |
Thermo Scientific™ Docetaxel (≥99%) is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree (Taxus baccata).
It is an antineoplastic and antimicrotubule agent widely used in cancer research, pharmacology, and cell biology. Docetaxel promotes microtubule polymerization and inhibits depolymerization, leading to microtubule stabilization, cell-cycle arrest, and apoptosis in proliferating cells.
Due to its potent antimitotic and anti-angiogenic properties, Docetaxel is extensively employed as a research compound in tumor biology, drug delivery studies, and cancer therapeutics development.
Key Features
- High Purity: ≥99% (HPLC) for reproducible results in biochemical and cellular assays.
- Second-Generation Taxane: More potent and soluble than paclitaxel (Taxol).
- Mechanism of Action: Promotes tubulin assembly and inhibits microtubule depolymerization, causing mitotic arrest and apoptosis.
- Antineoplastic and Cytotoxic: Active against a broad spectrum of tumor cell lines.
- Research Grade: Ideal for oncology, pharmacology, and nanocarrier formulation studies.
- Stable Solid Form: White crystalline powder for easy handling and storage.
- Research Use Only (RUO): Not intended for diagnostic or therapeutic use.
Chemical Identifiers
| Property | Value |
|---|---|
| Chemical Name (IUPAC) | (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate |
| Synonyms | Docetaxel anhydrous, Docetaxel trihydrate, TXL, Taxotere® analogue |
| CAS Number | 114977-28-5 |
| Molecular Formula | C₄₃H₅₃NO₁₄ |
| Molecular Weight | 807.89 g/mol |
| InChI Key | ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
| SMILES | CC(=O)O[C@@]12CO[C@@H]1CC@H[C@]1(C)[C@@H]2C@H[C@]2(O)CC@HC(C)=C(C@@HC1=O)C2(C)C |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥99% |
| Form | Powder |
| Appearance | White to off-white crystalline powder |
| Mechanism | Microtubule stabilization and mitotic inhibition |
| Storage Conditions | Cool, dry place; tightly sealed |
| Solubility | Insoluble in water; soluble in ethanol and DMSO |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Studies on cell division inhibition, apoptosis induction, and tumor growth suppression.
- Pharmacology: Evaluation of docetaxel’s cytotoxicity and mechanism in cancer therapy models.
- Drug Delivery Research: Formulation of liposomal, micellar, and nanoparticle-based docetaxel systems.
- Molecular Biology: Research on angiogenesis inhibition via VEGF pathways.
- Toxicology: Investigation of docetaxel-induced lysosomal and autophagic activity in cancer cells.
References
- Mansour, M. et al. “Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death in Prostate Cancer Cells.” J Cancer. (2018) 9(23), 4536–4546.
- Wang, L. et al. “Inhibition of Notch Pathway Enhances the Anti-Tumor Effect of Docetaxel.” Stem Cell Res Ther. (2020) 11(1), 258.
- Muthu, M.S. et al. “TPGS Micelles for Targeted Co-Delivery of Docetaxel and Quantum Dots.” Biomaterials. (2012) 33(12), 3494–3501.
The Thermo Scientific™ Docetaxel (≥99%) is a high-purity, second-generation taxane that stabilizes microtubules and induces apoptosis, making it a critical reagent for oncology, pharmacology, and cell biology research.
Manufactured to Thermo Scientific’s exact standards, it provides consistent quality and purity for drug mechanism studies, formulation development, and anticancer research.
- Pack Size: 100mg 1g 500mg