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Thermo Scientific™ Oxaliplatin, HPLC >99%, 100mg
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Specifications:
| Application | Cell Analysis, Apoptosis | ||
| Storage Temperature | -20°C | ||
| Product Type | Biochemical Reagent | Forms | Solid |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₈H₁₄N₂O₄Pt |
Thermo Scientific™ Oxaliplatin (≥99%) is a third-generation platinum-based antineoplastic compound used widely in oncology and biochemical research.
It is structurally related to cisplatin and carboplatin, functioning as a DNA crosslinking agent that interferes with DNA replication and transcription, leading to apoptosis in proliferating cells.
This high-purity compound is ideal for use as a reference standard, cytotoxic agent, or coordination complex in platinum-based drug development and molecular biology studies.
Key Features
- High Purity: ≥98.5% (HPLC), meeting research-grade standards.
- Mechanism of Action: Forms inter- and intra-strand DNA crosslinks, inhibiting DNA synthesis.
- Platinum-Based Cytotoxic Agent: Used in cancer research and mechanistic pharmacology.
- Stable and Well-Characterized: Verified by conforming infrared spectrum.
- Physical Form: White to off-white crystalline powder with ≤0.5% loss on drying.
- Research Use Only (RUO): Not for diagnostic or therapeutic applications.
Chemical Identifiers
| Property | Value |
|---|---|
| IUPAC Name | (1R,2R)-cyclohexane-1,2-diamine; 1,3-dioxa-2-platinacyclopentane-4,5-dione |
| Synonyms | Oxaliplatin, (1R,2R)-DACH platinum(II) complex |
| CAS Number | 61825-94-3 |
| Molecular Formula | C₈H₁₄N₂O₄Pt |
| Molecular Weight | 397.29 g/mol |
| InChI Key | ZROHGHOFXNOHSO-WHMNLBETNA-L |
| SMILES | O=C1O[Pt]OC1=O.N[C@@H]1CCCC[C@H]1N |
| MDL Number | MFCD00866327 |
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | ≥98.5% |
| Form | Powder |
| Color | White to off-white |
| Infrared Spectrum | Conforms |
| Loss on Drying | ≤0.5% (1 g, 105 °C, 2 h) |
| Solubility | Soluble in water |
| Storage Conditions | Store in a cool, dry, well-ventilated place |
| Packaging | Glass bottle |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Mechanistic studies of DNA damage and apoptosis.
- Drug Discovery: Development of platinum-based chemotherapeutic agents.
- Molecular Biology: Investigation of DNA repair and crosslinking processes.
- Pharmacology: Studies of cytotoxicity, antitumor mechanisms, and cell-cycle regulation.
- Biochemical Research: Coordination chemistry and protein–metal complex formation studies.
The Thermo Scientific™ Oxaliplatin, 99% is a high-purity platinum-based research compound used for studies in oncology, pharmacology, and molecular biology.
As a potent DNA crosslinking agent, it is essential for exploring the mechanisms of platinum drug action and advancing the development of new anticancer therapies.