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Invitrogen™ Paclitaxel (Taxol Equivalent) – For Research Use Only (5mg), HPLC >98%
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Specifications:
| Application | cell Signalling, Apoptosis | ||
| Storage Temperature | -30°C to -10°C | ||
| Product Type | Biochemical Reagent | Forms | Lyophilized |
| Product Brand | Thermo Fisher Scientific™, Invitrogen | ||
| Product Grade | Molecular Biology | Formula | C₄₇H₅₁NO₁₄ |
Invitrogen™ Paclitaxel (formerly known as Taxol®) is a microtubule-stabilizing agent with a purity of >98% (HPLC), provided specifically for research use.
Paclitaxel promotes tubulin polymerization, forming stable microtubule aggregates that cannot be depolymerized by cold, calcium ions, or microtubule-disrupting drugs. This leads to G₂/M phase arrest and ultimately apoptosis in dividing cells.
This reagent is essential in cytoskeletal research, cancer biology, pharmacology, and cell cycle studies as a model compound for chemotherapeutic mechanism investigations.
Key Features
- High Purity: >98% (HPLC verified) for reproducible biological activity.
- Mechanism of Action: Promotes microtubule assembly and inhibits depolymerization.
- Cell Cycle Inhibition: Induces arrest at the G₂ and M phases.
- Cytoskeletal Research Tool: Ideal for investigating tubulin dynamics and mitotic checkpoint regulation.
- Formulation: Supplied as a lyophilized powder for convenient reconstitution and storage.
- Research Use Only (RUO): Not intended for diagnostic or therapeutic use.
Specifications
| Parameter | Specification |
|---|---|
| Purity (HPLC) | >98% |
| Form | Lyophilized powder |
| Target | Tubulin |
| Function | Cytoskeletal inhibitor |
| Mechanism | Microtubule stabilization and mitotic arrest |
| Quantity | 5 mg |
| Storage Conditions | −5 °C to −30 °C (freezer); protect from light |
| Shipping Conditions | Room temperature |
| Intended Use | Research Use Only (RUO) |
Applications
- Cancer Research: Investigating microtubule-targeting chemotherapeutics.
- Cell Biology: Studies of mitotic spindle formation, cell cycle regulation, and apoptosis.
- Pharmacology: Drug resistance, tubulin-binding, and cytotoxicity assays.
- Cytoskeletal Dynamics: Analysis of microtubule polymerization and depolymerization.
- Drug Discovery: Model system for testing novel taxane analogs.
The Invitrogen™ Paclitaxel (Taxol Equivalent) is a research-grade microtubule stabilizer that arrests cells in mitosis by preventing microtubule depolymerization.
With >98% purity and validated activity, it provides a reliable standard for cytoskeletal and cancer biology research, making it an essential reagent for studying tubulin dynamics, apoptosis, and chemotherapeutic mechanisms.