Thermo Scientific™ Pierce™ Streptavidin Magnetic Beads, 1 μm

Pierce™ Streptavidin Magnetic Beads are uniform, superparamagnetic microparticles designed for rapid and efficient capture of biotinylated molecules in both manual and high-throughput workflows. Engineered with recombinant streptavidin covalently attached via leach-resistant chemistry, these beads ensure stable biotin binding, high specificity, and minimal background—making them ideal for pull-down assays, co-immunoprecipitations, and DNA-protein interaction studies.

The beads are pre-blocked to prevent nonspecific interactions and offer nearly three times the biotin-binding capacity of conventional streptavidin beads, reducing reagent usage and improving signal clarity. They are validated for use with automated magnetic instruments, including Thermo Scientific KingFisher™ 96 and Flex Systems, as well as standard magnetic racks for benchtop use.

Key Features & Benefits

• High Binding Capacity – Outperforms typical beads with increased efficiency and reduced reagent consumption
• Low Background – Pre-blocked, non-aggregating beads minimize nonspecific protein binding
• Superior Compatibility – Validated for KingFisher platforms and manual magnetic workflows
• Robust Immobilization Chemistry – Streptavidin is covalently bound using stable, leach-resistant methods
• Versatile Applications – Ideal for nucleic acid purification, protein interaction studies, and complex lysate purification

Applications

• Immunoprecipitation of antigens using biotinylated antibodies
• Co-immunoprecipitation of protein complexes
• Pull-down of biotinylated bait proteins in protein–protein interaction studies
• Isolation of biotinylated DNA–protein complexes
• Capture of single-stranded or double-stranded biotinylated DNA or RNA
• Purification of biotin-labeled PCR products or oligonucleotides

Technical Specifications

Pierce™ Streptavidin Magnetic Beads provide an exceptional tool for magnetic affinity purification of biotinylated molecules, delivering high binding efficiency, low nonspecific interactions, and compatibility with automated or manual systems. These beads are well-suited for molecular biology, proteomics, genomics, and other demanding applications requiring precise and reproducible biotin–streptavidin interaction performance.