Thermo Scientific™ Trityl chloride 98%

Triphenylmethyl chloride (Trityl chloride) is a white to light beige crystalline compound commonly used as a protecting group reagent in organic synthesis, especially in peptide chemistry and nucleoside modification. Thermo Scientific™ Triphenylmethyl chloride is supplied at ≥98% purity, ensuring reliable performance in acid-sensitive reactions, dehydration procedures, and Grignard reagent preparation.

The trityl group is particularly useful in protecting hydroxyl, amino, and thiol functionalities during multistep synthesis, due to its ease of introduction and selective removal under mildly acidic conditions. It is also a precursor in the synthesis of trityl-based dyes, stabilizers, and ligands.

Key Features & Benefits

• High Purity (≥98%)
  Verified by argentometric titration and HPLC for consistent reactivity.
• Stable Protecting Group Reagent
  Ideal for protecting amines, alcohols, and thiols in multistep synthesis.
• Versatile Synthetic Intermediate
  Useful in organometallic chemistry, dye synthesis, and functional group protection.
• Well-Characterized Identity
  IR spectrum conforms; melting point range 109–113°C ensures compound integrity.
• Powder/Crystal Form
  Easy to weigh, store, and dissolve in standard organic solvents.

Chemical Identity & Properties

Applications

• Protecting Group Chemistry
  • Used to protect hydroxyl (OH), amino (NH₂), and thiol (SH) groups
  • Easily cleaved under mild acidic conditions (e.g., with TFA)
• Organic & Peptide Synthesis
  • Common in solid-phase synthesis and combinatorial libraries
• Dye & Stabilizer Synthesis
  • Intermediate for trityl-based dyes and antioxidants
• Grignard Reagent Preparation
  • Starting material for trityl Grignard reagents in arylation chemistry
• Ligand and Sensor Development
  • Precursor for sterically hindered ligands or bulk group modifications

Thermo Scientific™ Triphenylmethyl Chloride (98%) is a high-purity, research-grade reagent that plays a vital role in organic synthesis workflows, especially for functional group protection, multistep reaction schemes, and nucleoside modification protocols. Its ease of use, selective reactivity, and broad compatibility make it indispensable in both academic and industrial synthetic labs.