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Specifications:
| Application | Organic Synthesis | ||
| Storage Temperature | Ambient | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₃H₅ClO |
Thermo Scientific™ Propionyl Chloride is a clear to pale yellow, highly reactive acyl chloride with ≥97.5% purity (by GC). It is commonly used as a propionylating agent and acylation reagent in the synthesis of pharmaceuticals, agrochemicals, textile auxiliaries, and organic peroxide initiators. This moisture-sensitive compound is an essential building block for manufacturing APIs, fine chemicals, and specialty reagents.
Applications
- Pharmaceutical Synthesis: Intermediate in the synthesis of ibuprofen, ketoprofen, and other NSAIDs.
- Agrochemical Manufacturing: Used in the preparation of crop protection agents and pesticide intermediates.
- Dye & Textile Industries: Precursor in the manufacture of colorants and textile auxiliaries.
- Specialty Chemicals: Useful in the production of organic peroxides and tailored acyl derivatives.
Chemical & Physical Properties
| Property | Value |
|---|---|
| Purity (Assay by GC) | ≥97.5% |
| Appearance | Clear, colorless to pale yellow liquid |
| Refractive Index (20 °C) | 1.4010 – 1.4070 |
| Color (APHA) | ≤20 |
| Identification (FTIR) | Conforms |
| Density (approximate) | ~1.06 g/mL |
| Boiling Point | ~80–82 °C |
| Solubility | Reacts with water |
Reactivity & Storage
- Moisture-Sensitive: Hydrolyzes in the presence of water, releasing hydrogen chloride gas.
- Incompatibilities: Alcohols, oxidizers, strong bases, and moisture.
- Storage Conditions: Store in a cool, dry, well-ventilated area away from moisture. Use inert atmosphere if possible.
Ordering Information
| Catalog Number | Quantity | Packaging |
|---|---|---|
| A10940.22 | 100 g | Glass bottle |
| A10940.36 | 500 g | Glass bottle |
| A10940.0E | 2500 g | Plastic drum |
Safety & Handling
- Corrosive and lachrymatory—use with appropriate personal protective equipment (PPE).
- Perform handling under a chemical fume hood.
- Avoid exposure to moisture and humidity.
Thermo Scientific™ Propionyl Chloride, 98% is a versatile reagent-grade chemical used in synthetic organic chemistry. Its high purity and consistent reactivity make it ideal for industrial, pharmaceutical, and academic R&D applications that require reliable acylation or propionylation conditions.
- Pack Size: 100g 500g 2.5 Kg