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Fmoc-Asn-OH, also known as Fmoc-protected L-asparagine, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and an unprotected carboxamide side chain, allowing controlled peptide elongation while preserving the natural asparagine functionality within synthetic peptides.
Asparagine is a polar amino acid that plays an important role in hydrogen bonding, protein folding, molecular recognition, glycosylation-related studies, and peptide–protein interactions. Fmoc-Asn-OH is therefore a valuable building block for custom peptide synthesis, pharmaceutical research, proteomics, bioorganic chemistry, structural biology, and drug discovery applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥97.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Asparagine Building Block | Enables incorporation of asparagine residues into synthetic peptides |
| Polar Side Chain | Supports hydrogen bonding and peptide–protein interaction studies |
| High Enantiomeric Purity | ≥99.5% for consistent stereochemical performance |
| SPPS Compatible | Suitable for peptide synthesis using appropriate coupling strategies |
| Research Applications | Ideal for proteomics, drug discovery, protein engineering, and bioorganic chemistry |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Asn-OH, ≥97.0% HPLC |
| Synonym | Fmoc-protected L-asparagine |
| CAS Number | 71989-16-7 |
| Empirical Formula | C₁₉H₁₈N₂O₅ |
| Molecular Weight | 354.36 g/mol |
| MDL Number | MFCD00037132 |
| UNSPSC Code | 12352209 |
| EC Index Number | 276-252-2 |
| Form | Powder |
| Melting Point | 175–190 °C |
| Assay | ≥97.0% by HPLC |
| Enantiomeric Purity | ≥99.5% |
| Water Content | ≤1.0% by Karl Fischer titration |
| Storage Temperature | 2–30 °C |
| Functional Groups | Fmoc, amide, carboxylic acid |
Applications
Fmoc-Asn-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of asparagine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Proteomics and biochemical research
- Protein engineering and structural biology studies
- Enzyme-substrate and molecular recognition studies
- Hydrophilic peptide synthesis
- Bioorganic chemistry and peptidomimetic synthesis
- Protein-ligand interaction and glycosylation-related research
Coupling Compatibility Note
Fmoc-Asn-OH is commonly used in peptide synthesis workflows where careful coupling conditions are required for asparagine-containing sequences. Carbodiimide-based coupling strategies may be preferred in some protocols to help reduce unwanted side reactions associated with certain uronium or phosphonium coupling reagents.
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 8522030005 | 5 g |
| 8522030025 | 25 g |
| 8522030100 | 100 g |
Storage & Handling
Store at 2–30 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Specification: Fmoc-Asn-OH
Fmoc-Asn-OH, also known as Fmoc-protected L-asparagine, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and an unprotected carboxamide side chain, allowing controlled peptide elongation while preserving the natural asparagine functionality within synthetic peptides.
Asparagine is a polar amino acid that plays an important role in hydrogen bonding, protein folding, molecular recognition, glycosylation-related studies, and peptide–protein interactions. Fmoc-Asn-OH is therefore a valuable building block for custom peptide synthesis, pharmaceutical research, proteomics, bioorganic chemistry, structural biology, and drug discovery applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥97.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Asparagine Building Block | Enables incorporation of asparagine residues into synthetic peptides |
| Polar Side Chain | Supports hydrogen bonding and peptide–protein interaction studies |
| High Enantiomeric Purity | ≥99.5% for consistent stereochemical performance |
| SPPS Compatible | Suitable for peptide synthesis using appropriate coupling strategies |
| Research Applications | Ideal for proteomics, drug discovery, protein engineering, and bioorganic chemistry |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Asn-OH, ≥97.0% HPLC |
| Synonym | Fmoc-protected L-asparagine |
| CAS Number | 71989-16-7 |
| Empirical Formula | C₁₉H₁₈N₂O₅ |
| Molecular Weight | 354.36 g/mol |
| MDL Number | MFCD00037132 |
| UNSPSC Code | 12352209 |
| EC Index Number | 276-252-2 |
| Form | Powder |
| Melting Point | 175–190 °C |
| Assay | ≥97.0% by HPLC |
| Enantiomeric Purity | ≥99.5% |
| Water Content | ≤1.0% by Karl Fischer titration |
| Storage Temperature | 2–30 °C |
| Functional Groups | Fmoc, amide, carboxylic acid |
Applications
Fmoc-Asn-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of asparagine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Proteomics and biochemical research
- Protein engineering and structural biology studies
- Enzyme-substrate and molecular recognition studies
- Hydrophilic peptide synthesis
- Bioorganic chemistry and peptidomimetic synthesis
- Protein-ligand interaction and glycosylation-related research
Coupling Compatibility Note
Fmoc-Asn-OH is commonly used in peptide synthesis workflows where careful coupling conditions are required for asparagine-containing sequences. Carbodiimide-based coupling strategies may be preferred in some protocols to help reduce unwanted side reactions associated with certain uronium or phosphonium coupling reagents.
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 8522030005 | 5 g |
| 8522030025 | 25 g |
| 8522030100 | 100 g |
Storage & Handling
Store at 2–30 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Specification: Fmoc-Asn-OH
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Specifiche
| Pack Size | 100g, 5g, 25g |