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Fmoc-Ile-OH, also known as Fmoc-L-Isoleucine, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group, allowing selective deprotection during stepwise peptide elongation.
Isoleucine is a branched-chain essential amino acid that contributes to hydrophobic interactions, protein folding, peptide stability, and secondary structure formation. This makes Fmoc-Ile-OH a valuable building block for custom peptide synthesis, pharmaceutical research, proteomics, enzyme-substrate studies, and protein engineering applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by titration; assay verified by HPLC |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Isoleucine Building Block | Enables incorporation of isoleucine residues into synthetic peptides |
| Hydrophobic Amino Acid | Supports peptide folding, stability, and hydrophobic interactions |
| SPPS Compatible | Suitable for solid-phase peptide synthesis and peptide modification |
| Research Applications | Ideal for peptide chemistry, pharmaceutical research, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Ile-OH, ≥98.0% |
| Synonym | Fmoc-L-Isoleucine |
| CAS Number | 71989-23-6 |
| Empirical Formula | C₂₁H₂₃NO₄ |
| Molecular Weight | 353.41 g/mol |
| Beilstein Registry Number | 4716717 |
| EC Number | 276-255-9 |
| MDL Number | MFCD00037125 |
| PubChem Substance ID | 57651048 |
| Optical Activity | [α]²⁰/D -12 ± 1°; c = 1% in DMF |
| Form | Solid |
| Melting Point | 145–147 °C |
| Assay | ≥98.0% by titration; verified by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Ile-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of isoleucine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Proteomics and biochemical research
- Bioorganic chemistry and peptidomimetic synthesis
- Studies involving hydrophobic peptide regions and protein stability
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47628-50G-F | 50 g |
| 47628-250G-F | 250 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
No resources are currently available for this product.
Fmoc-Ile-OH, also known as Fmoc-L-Isoleucine, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group, allowing selective deprotection during stepwise peptide elongation.
Isoleucine is a branched-chain essential amino acid that contributes to hydrophobic interactions, protein folding, peptide stability, and secondary structure formation. This makes Fmoc-Ile-OH a valuable building block for custom peptide synthesis, pharmaceutical research, proteomics, enzyme-substrate studies, and protein engineering applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by titration; assay verified by HPLC |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Isoleucine Building Block | Enables incorporation of isoleucine residues into synthetic peptides |
| Hydrophobic Amino Acid | Supports peptide folding, stability, and hydrophobic interactions |
| SPPS Compatible | Suitable for solid-phase peptide synthesis and peptide modification |
| Research Applications | Ideal for peptide chemistry, pharmaceutical research, proteomics, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Ile-OH, ≥98.0% |
| Synonym | Fmoc-L-Isoleucine |
| CAS Number | 71989-23-6 |
| Empirical Formula | C₂₁H₂₃NO₄ |
| Molecular Weight | 353.41 g/mol |
| Beilstein Registry Number | 4716717 |
| EC Number | 276-255-9 |
| MDL Number | MFCD00037125 |
| PubChem Substance ID | 57651048 |
| Optical Activity | [α]²⁰/D -12 ± 1°; c = 1% in DMF |
| Form | Solid |
| Melting Point | 145–147 °C |
| Assay | ≥98.0% by titration; verified by HPLC |
| Storage Temperature | 2–8 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Ile-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of isoleucine residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Enzyme-substrate and inhibitor studies
- Protein engineering and structural biology research
- Proteomics and biochemical research
- Bioorganic chemistry and peptidomimetic synthesis
- Studies involving hydrophobic peptide regions and protein stability
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 47628-50G-F | 50 g |
| 47628-250G-F | 250 g |
Storage & Handling
Store at 2–8 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
No resources are currently available for this product.
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Specifiche
| Pack Size | 250g, 50g |