1,3-Dipalmitoyl-2-chloropropanediol-d5

1,3-Dipalmitoyl-2-chloropropanediol-d5 is a chemically synthesized, deuterium-labeled compound, primarily used in biochemical and pharmacological research. This molecule features two palmitoyl chains attached to a chlorinated glycerol backbone, with five hydrogen atoms replaced by deuterium. Its labeled nature makes it valuable in mass spectrometry and isotope tracing studies.

Chemical Properties

Applications

1. Stable Isotope Labeling:
   • Used as an internal standard for quantitative analysis in mass spectrometry due to its isotopic labeling.
   • Supports lipidomics studies, including glycerolipid and glycerophospholipid metabolism.
2. Biochemical Studies:
   • Investigates enzymatic activities involving chlorinated glycerolipids.
   • Helps elucidate the mechanisms of lipid transport, metabolism, and signaling pathways.
3. Pharmacological Research:
   • Evaluates chlorinated lipids' interactions with biological membranes and proteins.
   • Explores potential roles in disease states, such as inflammatory and metabolic disorders.
4. Analytical Chemistry:
   • Enhances accuracy in chromatography and mass spectrometry workflows.
   • Useful in isotope dilution assays for quantifying lipids in biological samples.

Key Features

1. Deuterium Labeling:
   • Five deuterium atoms provide distinct mass spectral peaks, facilitating precise tracking and quantification in complex mixtures.
2. High Purity:
   • Synthesized to meet stringent purity standards, ensuring reliability in experimental applications.
3. Lipid-Like Structure:
   • Mimics native lipid behavior, enabling realistic biological modeling and interactions.

Physical Properties

Handling and Safety

1. Safety Precautions:
   • Handle in a well-ventilated area while wearing appropriate personal protective equipment (PPE), including gloves and goggles.
   • Avoid inhalation, ingestion, and skin or eye contact.
2. Hazard Classification:
   • Chlorinated compounds may exhibit reactivity; consult the Safety Data Sheet (SDS) for detailed information.
   • Ensure proper waste disposal per local and institutional regulations.

Applications in Research

1. Lipidomics:
   • Investigating lipid modifications, including chlorinated derivatives, in cellular and tissue samples.
2. Disease Studies:
   • Examining lipid biomarkers in conditions like atherosclerosis, inflammation, and oxidative stress.
3. Drug Development:
   • Exploring potential therapeutic or adverse effects of chlorinated lipids in pharmacokinetics and pharmacodynamics.

1,3-Dipalmitoyl-2-chloropropanediol-d5 (D486842) is a versatile and valuable tool in lipid research, isotope labeling, and analytical applications. Its combination of isotopic labeling, lipid-like behavior, and biochemical relevance makes it an essential compound for advancing studies in lipidomics, metabolism, and pharmacology.