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Thermo Scientific™ Scopolamine hydrobromide trihydrate 99%
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Specifications:
| Application | cell Signalling | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Molecular Biology | Formula | C₁₇H₂₁NO₄ |
High-Purity Anticholinergic Agent for Neuroscience and Pharmacological Research
Scopolamine hydrobromide trihydrate is a high-purity salt form of scopolamine, a tropane alkaloid derived from plants in the Solanaceae family (e.g., Hyoscyamus niger, Atropa belladonna). It exhibits potent anti-muscarinic, anti-emetic, and anti-spasmodic activities by competitively blocking muscarinic acetylcholine receptors (mAChRs). Supplied at ≥99% purity, this compound is widely used in neuroscience and pharmacological research—especially in animal models of memory impairment and Alzheimer’s disease.
Key Features & Benefits
- High Purity (≥99%): Suitable for reliable and reproducible research results
- Pharmacologically Relevant: Exhibits potent competitive anti-muscarinic activity
- Animal Model Utility: Frequently used to induce transient cognitive deficits in rodents
- Versatile Applications: Useful in memory, neurodegeneration, and cholinergic signaling research
- Available Formats: Supplied in 1 g, 5 g, and 25 g glass bottles
Chemical & Physical Properties
| Attribute | Details |
|---|---|
| Product Name | Scopolamine Hydrobromide Trihydrate |
| CAS Number | 6533-68-2 |
| Chemical Formula | C₁₇H₂₈BrNO₇ |
| Molecular Weight | 438.32 g/mol |
| Purity | ≥99% |
| Appearance | Colorless to white crystalline powder or crystals |
| Solubility | Soluble in water |
| Specific Optical Rotation | –24° to –27° (c = 5, H₂O at 20 °C, 589 nm) |
| Water Content (Karl Fischer) | 10–13% |
| Assay (Titration with HClO₄) | ≥98.5% |
Applications
- Neuroscience Research: Used to study cholinergic dysfunction and learning and memory pathways
- Alzheimer’s Disease Modeling: Induces cognitive deficits in rodents for behavioral, molecular, and pharmacological testing
- Pharmacology: Characterization of muscarinic receptor subtypes, especially M1 mAChRs
- Toxicology: Used in dose-response studies to evaluate the effects of anti-cholinergic load
- Education & Training: Demonstrates the physiological impact of acetylcholine inhibition
Ordering Information
| Catalog Number | Quantity | Packaging |
|---|---|---|
| 161750010 | 1 g | Glass bottle |
| 161750050 | 5 g | Glass bottle |
| 161750250 | 25 g | Glass bottle |
Safety & Handling
- Storage: Store at room temperature in a dry, ventilated area
- Hazard: Toxic if swallowed or absorbed through skin; use appropriate PPE
- Regulatory Status: For Research Use Only (RUO); not for human or veterinary diagnostic or therapeutic use
Thermo Scientific™ Scopolamine Hydrobromide Trihydrate, 99% is a trusted and widely used research compound for exploring central nervous system pharmacology, cholinergic receptor dynamics, and memory-related disorders. With excellent purity and detailed specification control, it is the ideal tool for laboratories conducting Alzheimer’s disease research, behavioral neuroscience, and receptor pharmacology.
- Pack Size: 1g 5g 25g