Thermo Scientific™ Rifampicin 95%

Thermo Scientific Rifampicin is a semisynthetic antibiotic with a purity of at least 95%, making it suitable for use in microbiology, pharmaceutical, and biochemical research. Rifampicin exhibits potent antimicrobial activity, particularly against gram-positive bacteria, and is a vital tool for studying bacterial RNA synthesis and treating infections caused by Mycobacterium species, including tuberculosis and leprosy.

Chemical and Physical Properties:

• Synonyms:
  • Rifampin
  • 3-(4-Methylpiperazinyliminomethyl)rifamycin SV
  • Rifamycin AMP
• Chemical Formula: C₄₃H₅₈N₄O₁₂
• Molecular Weight: 822.95 g/mol
• CAS Number: 13292-46-1
• MDL Number: MFCD00151389

Physical Properties:

• Appearance: Light orange to red-brown powder
• Purity: ≥95% (HPLC analysis)
• Melting Point: 183°C
• Storage Temperature: Store in a refrigerator (2–8°C)
• Loss on Drying: ≤2% (100 mg, 60°C, 4 hours under vacuum)

Applications:

1. Pharmaceutical Research:

• Antibiotic Therapy Studies:
  • Essential for research on tuberculosis (caused by Mycobacterium tuberculosis) and leprosy (Mycobacterium leprae).
  • Investigating its mechanism of action as an inhibitor of bacterial RNA polymerase.
• Multidrug Therapy Research:
  • Studied in combination with other antibiotics to prevent the emergence of drug-resistant bacterial strains.

2. Microbiology and Biochemistry:

• Antimicrobial Activity Studies:
  • Used to evaluate its bactericidal effects on gram-positive and some gram-negative bacteria.
• RNA Synthesis Inhibition:
  • A critical tool for understanding transcriptional processes by blocking bacterial RNA polymerase.
• Resistance Mechanism Studies:
  • Used to investigate genetic mutations in bacteria that confer resistance to rifampicin.

3. Cell Culture Applications:

• Contamination Control:
  • Used in cell culture systems to control bacterial contamination without affecting eukaryotic cells.

4. Diagnostics Development:

• Tuberculosis Diagnostics:
  • Used in laboratory settings to test the efficacy of diagnostic kits designed to detect Mycobacterium tuberculosis.

Specifications:

• Infrared Spectrum: Conforms to reference standard.
• Purity (HPLC): ≥94%
• Loss on Drying: ≤2%
• Solubility: Soluble in DMSO and aqueous solutions at specified conditions.

Packaging Information:

• Pack Sizes and Catalog Numbers:
  • 1 g: Catalog No. ACRO455620010
  • 5 g: Catalog No. ACRO455620050
  • 25 g: Catalog No. ACRO455620250
• Packaging Type: Secure glass bottles for long-term storage and stability.

Storage and Handling:

• Storage:
  • Store at refrigerated temperatures (2–8°C) to maintain stability and prevent degradation.
• Handling:
  • Use personal protective equipment (PPE), including gloves and goggles, to avoid direct contact.
  • Handle in a well-ventilated area to minimize inhalation of powder.

Key Features:

1. High Purity: Guaranteed ≥95% purity ensures reliability and reproducibility in research experiments.
2. Broad Antimicrobial Activity: Active against gram-positive bacteria and certain gram-negative strains.
3. Critical Research Tool: Widely used in studies on RNA transcription, bacterial resistance, and antibiotic efficacy.
4. Cell Culture Tested: Proven suitable for use in cell culture systems.

Thermo Scientific Rifampicin is a versatile and high-purity antibiotic that is indispensable in pharmaceutical, microbiological, and biochemical research. With its potent activity against bacterial pathogens, particularly Mycobacterium species, and its use in studying bacterial RNA synthesis, this product provides a reliable solution for a wide range of laboratory applications.