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Thermo Scientific™ Oxoid™ Fosfomycin FOS Antimicrobial Susceptibility Disks
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Specifications:
| Application | Antimicrobial Susceptibility and Resistance Testing (AST) |
| Storage Temperature | -20°C |
| Product Type | Antibiotic Disc |
| Product Brand | Thermo Fisher Scientific™, Oxoid |
| Product Grade | Microbiology grade |
Thermo Scientific™ Oxoid™ Fosfomycin Antimicrobial Susceptibility Discs are high-quality, cartridge-packed discs for manual antimicrobial susceptibility testing (AST) using the disk diffusion method. These discs are impregnated with either 50 µg or 200 µg of fosfomycin, and the 200 µg variant includes 50 µg of glucose-6-phosphate (G6P) as required by EUCAST for reliable fosfomycin susceptibility testing in Escherichia coli.
The discs are ideal for determining phenotypic resistance to fosfomycin, a broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacteria. Fosfomycin is increasingly important in the management of multidrug-resistant urinary tract infections (UTIs) and is a key agent in antimicrobial stewardship.
Available Formats and Catalog Numbers
| Catalog Number | Antibiotic Code | Label | Concentration | Intended Use |
|---|---|---|---|---|
| CT0183B | FOT | FOS50 | 50 µg | General use for susceptible organisms |
| CT0758B | FOT | FOT200 | 200 µg + 50 µg G6P | EUCAST-defined method for E. coli only |
Key Features and Benefits
- EUCAST-Compliant 200 µg Disc: Includes glucose-6-phosphate for accurate testing of E. coli
- Validated for Use in Manual AST: Supports accurate categorization of susceptibility profiles
- User-Friendly Cartridge System: Spring-loaded design for easy and contamination-free application
- Desiccant-Sealed Packaging: Ensures <2% moisture content for optimal stability and shelf life
- Reliable Phenotypic Assessment: Helps detect resistance, inoculum issues, synergy, and contamination
- Essential for UTI Treatment Monitoring: Fosfomycin is a first-line agent for uncomplicated UTIs
Important Usage Notes
- The 200 µg disc (CT0758B) should be used only for testing E. coli by disk diffusion per EUCAST guidelines.
- For Enterobacterales and Staphylococcus spp., fosfomycin susceptibility must be determined via MIC testing.
Intended Use
These discs are designed for semi-quantitative agar diffusion susceptibility testing of pure, agar-grown cultures. They aid in guiding clinical treatment by determining bacterial susceptibility to fosfomycin. These are not automated or companion diagnostics and are for professional use only.
Specifications
| Parameter | Value |
|---|---|
| Antibiotic Agent | Fosfomycin (± Glucose-6-Phosphate) |
| Antibiotic Code | FOS |
| Disc Potencies | 50 µg, 200 µg |
| Format | 6 mm paper disc, cartridge format |
| Packaging | 50 discs/cartridge; 5 cartridges per pack |
| Compliance | EUCAST, CLSI, BSAC, DIN |
| Use Classification | In Vitro Diagnostic Use (IVD) |
| Storage | Dry, room temperature; <2% moisture content |
Applications
- Phenotypic detection of fosfomycin resistance in E. coli
- AST in urinary tract infection isolates
- Routine susceptibility testing in clinical microbiology labs
- AMR surveillance and carbapenem-sparing therapy screening
- Validation of fosfomycin use in multidrug-resistant Gram-negative infections
Thermo Scientific™ Oxoid™ Fosfomycin AST Discs (FOS50 and FOT200) offer a reliable, compliant, and easy-to-use solution for detecting fosfomycin susceptibility. With options suitable for both general screening and EUCAST-specific workflows, these discs are essential for modern AST panels, especially for tackling MDR E. coli in urinary tract infections.
- Drug Concentration: 50 µg 200 µg + 50 µg G6P (EUCAST-defined method for E. coli only)