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Thermo Scientific™ Dizocilpine maleate, 99+%
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Specifications:
| Application | Analysis | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Laboratory Chemical | Forms | Powder |
| Product Brand | Thermo Fisher Scientific™, thermo Scientific | ||
| Product Grade | Analytical grade | Formula | C₂₀H₁₉NO₄ |
Potent NMDA Receptor Antagonist
Dizocilpine maleate (commonly known as (+)-MK-801) is a high-affinity, non-competitive antagonist of the NMDA receptor. It interacts directly with the NMDA-associated ion channel to block calcium ion (Ca²⁺) influx and inhibit glutamate-mediated excitotoxicity, a key factor in various neurodegenerative diseases. With ≥99% purity, this research-grade compound is ideal for in vitro and in vivo studies in neuropharmacology, synaptic transmission, and neuroprotection.
Key Features & Benefits
- High-purity (≥99%) NMDA antagonist suitable for sensitive neurochemical assays
- Blocks NMDA receptor-associated Ca²⁺ influx, reducing neuronal depolarization
- Powerful neuroprotective tool in excitotoxic and ischemic brain injury models
- Active form of MK-801, widely referenced in CNS and behavioral neuroscience research
- Supplied as powder/crystalline solid; soluble in ethanol
Applications
- Neurotoxicity & excitotoxicity prevention studies
- NMDA receptor signaling pathway research
- Ischemia and traumatic brain injury models
- CNS drug screening and receptor binding assays
- Parkinson's and Huntington's disease models
- Modulation of dopaminergic gene expression (e.g., D2 receptor studies)
For Research Use Only (RUO). Not for diagnostic or therapeutic use.
Biochemical & Pharmacological Action
- Non-competitive NMDA receptor antagonist
- Binds to the ion channel site, preventing Ca²⁺ influx
- Demonstrates potent neuroprotection against glutamate-induced neuron loss
- Inhibits NMDA and quinolinic acid-mediated neurodegeneration
Chemical & Physical Properties
| Attribute | Value |
|---|---|
| CAS Number | 77086-22-7 |
| Synonym | (+)-MK-801, Dizocilpine |
| IUPAC Name | (1S,9R)-1-methyl-16-azatetracyclo[...] + maleic acid |
| Molecular Formula | C₂₀H₁₉NO₄ |
| Molecular Weight | 337.38 g/mol |
| Form | Powder / Crystalline powder |
| Purity | ≥99.0% (Proton NMR confirmed) |
| Solubility | Soluble in ethanol |
| Storage Conditions | Store in cool, dry place, tightly sealed |
Ordering Information
| Product Description | Catalog No. | Quantity |
|---|---|---|
| Dizocilpine Maleate (MK-801), ≥99% | J63917.MA | 10 mg |
| Dizocilpine Maleate (MK-801), ≥99% | J63917.MF | 50 mg |
References
- Lannes et al., Neuroscience (1995): Dizocilpine increases D2 receptor expression in striatal neurons.
- Salin et al., Neuroscience (1994): NMDA antagonism reverses neuropeptide Y neuron adaptation post-dopamine deafferentation.
Thermo Scientific™ Dizocilpine Maleate (MK-801) is a powerful tool for probing glutamatergic signaling and excitotoxic mechanisms in CNS disorders. With its high affinity for NMDA receptor channels and potent neuroprotective properties, it is widely used in academic and pharmaceutical neuroscience research to study synaptic plasticity, neurodegeneration, and behavioral pharmacology.
- Pack Size: 10mg 50mg