Thermo Scientific™ 2-Methyl-5-nitroimidazole-1-ethanol 99% (Metronidazole)

Thermo Scientific™ Metronidazole is a high-purity nitroimidazole antimicrobial compound (≥99%) used in research applications involving anaerobic bacteria, protozoa, and DNA-targeted therapeutics. This crystalline powder is supplied as part of the Thermo Scientific Chemicals (formerly Acros Organics) portfolio and supports investigations into nucleic acid synthesis inhibition, microbial DNA damage, and hypoxia-selective radiosensitization.

Metronidazole is selectively activated in anaerobic environments, producing reactive nitroso intermediates that covalently bind and disrupt DNA helices, inhibit bacterial nucleic acid synthesis, and lead to microbial cell death. Its broad-spectrum efficacy against Bacteroides, Clostridium, Peptostreptococcus, Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, and Helicobacter pylori makes it a valuable tool in microbiology, parasitology, and oncology research.

Key Features and Benefits

• High Analytical Purity: ≥99% (Titration ≥98.5%)
• Broad-Spectrum Activity: Effective against anaerobic protozoa and Gram-positive/Gram-negative anaerobic bacteria
• Mechanism-Based Research Tool: Covalently binds microbial DNA under anaerobic conditions
• Versatile Research Applications: From bacterial eradication studies to radiosensitization of hypoxic tumor cells
• Available in Multiple Quantities: Suitable for small-scale assays or high-volume workflows

Chemical and Physical Properties

Available Catalog Numbers and Packaging

Applications

• Antiprotozoal and antibacterial research
• Studies involving anaerobic microbial inhibition
• Research on Clostridium difficile, H. pylori, and other anaerobic pathogens
• DNA damage and repair mechanism studies
• Radiosensitization studies in oncology (hypoxic tumors)
• Experimental gut microbiome modulation

Storage and Handling

• Storage Conditions: Ambient temperature in dry, ventilated area
• Shelf Life: Refer to batch-specific Certificate of Analysis (COA)
• Safety: Use appropriate PPE and handle according to standard lab protocols; consult SDS for details

Thermo Scientific™ Metronidazole, 99%, is a trusted, high-purity compound for in vitro and in vivo research involving anaerobic bacteria, protozoa, and DNA-targeting therapeutic mechanisms. This product supports both routine microbiology assays and advanced biomedical investigations. Its versatility, proven mechanism of action, and analytical-grade quality make it a vital tool for researchers in microbiology, oncology, and molecular biology.