Sigma-Aldrich 2-Methyl-1-pentanol

2-Methyl-1-pentanol is a branched alcohol widely used in organic synthesis, solvent systems, and various industrial applications. Known for its high purity and consistent performance, it is frequently employed in research and industrial processes, including kinetic resolutions and thermodynamic studies.

Chemical and Physical Properties

Physical Characteristics

Molecular Structure

• SMILES String: CCCC(C)CO
• InChI: 1S/C6H14O/c1-3-4-6(2)5-7/h6-7H,3-5H2,1-2H3
• InChI Key: PFNHSEQQEPMLNI-UHFFFAOYSA-N

Applications

1. Kinetic Resolutions:
   • Utilized in nonaqueous, lipase-catalyzed kinetic resolution of racemic mixtures.
   • Example: Fixed bed reactor operations for enantiomer separation.
2. Thermodynamic Studies:
   • Measurement of molar excess enthalpies in binary mixtures with n-hexane and its isomers.
   • Employed in flow microcalorimetry for precise thermal property analysis.
3. Organic Synthesis:
   • Used as a building block in complex organic reactions.
   • Serves as a precursor for functionalized derivatives.
4. Solvent Systems:
   • Applied in systems requiring branched alcohols with specific boiling points and miscibility properties.

Advantages

• High Purity (99%): Ensures reliable and consistent performance in research and industrial applications.
• Thermal Stability: Boiling point and vapor pressure values support its use in varied temperature conditions.
• Versatile Solvent Properties: Suitable for kinetic resolutions, synthesis, and thermodynamic measurements.

Handling and Safety

• Storage: Store in a cool, well-ventilated area away from sources of ignition.
• Precautions: Avoid inhalation, ingestion, and skin contact. Use appropriate protective equipment.
• Disposal: Dispose of in accordance with local, regional, and national regulations.

References

1. Nonaqueous lipase-catalyzed kinetic resolution of racemic 2-methyl-1-pentanol in a fixed bed reactor.
2. Measurement of molar excess enthalpies of binary mixtures of 2-methyl-1-pentanol with n-hexane and its isomers using flow microcalorimetry.

Sigma-Aldrich 2-Methyl-1-pentanol offers high purity and performance, making it indispensable in research, thermodynamic studies, and chemical synthesis.