Thermo Scientific™ Ibuprofen, 99%

Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that acts as a non-selective cyclooxygenase (COX) inhibitor, providing analgesic, antipyretic, and anti-inflammatory effects. It is particularly effective in reducing inflammation-related pain and fever and is a standard reference compound in pharmaceutical, biochemical, and toxicological research.

Thermo Scientific™ Ibuprofen is offered at ≥99% HPLC purity, in solid form, for use in preclinical research, cell biology, pharmacokinetics, and drug interaction studies.

Available Pack Sizes

Chemical & Physical Specifications

Biological Activity

• Mechanism of Action: Inhibits COX-1 and COX-2 enzymes, with a preference for COX-1
• Pharmacological Class: Nonsteroidal anti-inflammatory drug (NSAID)
• Therapeutic Effects:
  • Reduces prostaglandin synthesis
  • Lowers inflammation, pain, and fever
  • Accumulates in synovial fluid in inflamed joints
• Interactions: May interfere with antihypertensive drugs such as ACE inhibitors, beta-blockers, ARBs, and diuretics

Applications in Research

Ibuprofen is used across diverse research areas:

• Pulmonary and Vascular Biology
  • Studied for its effects on neonatal lung development and vasoregulation
• Cancer Biology
  • Investigated in cholangiocarcinoma cell lines for its impact on apoptosis, proliferation, and histological changes
• Drug Formulation Research
  • Used in the development of therapeutic deep eutectic solvents (THEDES) for controlled delivery and enhanced bioactivity
• Toxicology and Pharmacokinetics
  • Explored for its drug-drug interaction potential and central nervous system penetration

Preparation & Handling

• Handling: Use appropriate PPE; avoid inhalation of dust
• Storage: Store at room temperature in a cool, dry, light-protected area
• Reconstitution: Dissolve in ethanol, DMSO, or other appropriate solvent depending on assay requirements

Thermo Scientific™ Ibuprofen (≥99%) is a pharmaceutical-grade NSAID suited for inflammatory, analgesic, cardiovascular, toxicological, and formulation research. Its high purity, known pharmacodynamics, and relevance in drug development and disease modeling make it an indispensable compound in biomedical and pharmaceutical research.