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Fmoc-Trp-OH, also known as Fmoc-protected L-tryptophan, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and an unprotected indole side chain, making it a useful tryptophan building block for peptide synthesis workflows where Boc side-chain protection is not required.
Tryptophan is an aromatic amino acid that plays an important role in protein folding, hydrophobic interactions, enzyme recognition, ligand binding, and fluorescence-based studies. Fmoc-Trp-OH is therefore widely used in custom peptide synthesis, pharmaceutical research, proteomics, structural biology, protein engineering, bioorganic chemistry, and drug discovery applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Unprotected Indole Group | Useful where Boc-protected tryptophan is not required |
| High Enantiomeric Purity | ≥99.0% for consistent stereochemical performance |
| SPPS Compatible | Suitable for incorporation of tryptophan residues into synthetic peptides |
| Research Applications | Ideal for peptide chemistry, proteomics, drug discovery, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Trp-OH, ≥98.0% HPLC |
| Synonym | Fmoc-protected L-tryptophan |
| CAS Number | 35737-15-6 |
| Empirical Formula | C₂₆H₂₂N₂O₄ |
| Molecular Weight | 426.46 g/mol |
| MDL Number | MFCD00037126 |
| UNSPSC Code | 12352209 |
| EC Index Number | 252-706-5 |
| Optical Activity | [α]²⁰/D -21 ± 2°; c = 1% in DMF |
| Form | Powder |
| Assay | ≥98.0% by HPLC |
| Enantiomeric Purity | ≥99.0% |
| Water Content | ≤1.0% by Karl Fischer titration |
| Storage Temperature | 2–30 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Trp-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of tryptophan residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Proteomics and biochemical research
- Protein engineering and structural biology studies
- Fluorescence-based peptide and protein studies
- Enzyme-substrate and ligand-binding interaction studies
- Bioorganic chemistry and peptidomimetic synthesis
- Workflows requiring tryptophan without Boc side-chain protection
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 8522070005 | 5 g |
| 8522070100 | 100 g |
| 8522071000 | 1 kg |
Storage & Handling
Store at 2–30 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Specification: Fmoc-Trp-OH
Fmoc-Trp-OH, also known as Fmoc-protected L-tryptophan, is a high-purity, N-protected amino acid derivative used in Fmoc-based solid-phase peptide synthesis (SPPS). It features an Fmoc-protected α-amino group and an unprotected indole side chain, making it a useful tryptophan building block for peptide synthesis workflows where Boc side-chain protection is not required.
Tryptophan is an aromatic amino acid that plays an important role in protein folding, hydrophobic interactions, enzyme recognition, ligand binding, and fluorescence-based studies. Fmoc-Trp-OH is therefore widely used in custom peptide synthesis, pharmaceutical research, proteomics, structural biology, protein engineering, bioorganic chemistry, and drug discovery applications.
Key Features
| Feature | Details |
|---|---|
| High Purity | ≥98.0% by HPLC for reliable peptide synthesis |
| Fmoc Protection | Protects the α-amino group for controlled Fmoc-SPPS workflows |
| Unprotected Indole Group | Useful where Boc-protected tryptophan is not required |
| High Enantiomeric Purity | ≥99.0% for consistent stereochemical performance |
| SPPS Compatible | Suitable for incorporation of tryptophan residues into synthetic peptides |
| Research Applications | Ideal for peptide chemistry, proteomics, drug discovery, and protein engineering |
Chemical Properties & Identifiers
| Property | Value |
|---|---|
| Product Name | Fmoc-Trp-OH, ≥98.0% HPLC |
| Synonym | Fmoc-protected L-tryptophan |
| CAS Number | 35737-15-6 |
| Empirical Formula | C₂₆H₂₂N₂O₄ |
| Molecular Weight | 426.46 g/mol |
| MDL Number | MFCD00037126 |
| UNSPSC Code | 12352209 |
| EC Index Number | 252-706-5 |
| Optical Activity | [α]²⁰/D -21 ± 2°; c = 1% in DMF |
| Form | Powder |
| Assay | ≥98.0% by HPLC |
| Enantiomeric Purity | ≥99.0% |
| Water Content | ≤1.0% by Karl Fischer titration |
| Storage Temperature | 2–30 °C |
| Functional Groups | Fmoc, amine, carboxylic acid |
Applications
Fmoc-Trp-OH is suitable for:
- Fmoc-based solid-phase peptide synthesis
- Incorporation of tryptophan residues into synthetic peptides
- Custom peptide synthesis and peptide modification
- Peptide-based pharmaceutical and drug discovery research
- Proteomics and biochemical research
- Protein engineering and structural biology studies
- Fluorescence-based peptide and protein studies
- Enzyme-substrate and ligand-binding interaction studies
- Bioorganic chemistry and peptidomimetic synthesis
- Workflows requiring tryptophan without Boc side-chain protection
Ordering Information
| Catalog Number | Quantity |
|---|---|
| 8522070005 | 5 g |
| 8522070100 | 100 g |
| 8522071000 | 1 kg |
Storage & Handling
Store at 2–30 °C in a dry, tightly sealed container. Protect from moisture, oxidation, and extreme temperatures. Handle in a suitable laboratory environment using appropriate personal protective equipment, including gloves, lab coat, and safety goggles.
Research Use Statement
For Research Use Only (RUO). Not intended for diagnostic or therapeutic use.
Specification: Fmoc-Trp-OH
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Spezifikationen
| Pack Size | 1kg, 100g, 5g |