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MCE Retinoic Acid (ATRA) Analytical Standard, ≥99.73%
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CAS Number :
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Specifications:
| Application | Analytical Chemistry, chromatography | ||
| Storage Temperature | Room Temperature | ||
| Product Type | Standards | Forms | Solid |
| Product Brand | MedChem Express | ||
| Product Grade | Analytical grade | ||
The Retinoic Acid (Standard)—also known as all-trans-Retinoic acid (ATRA)—is a high-purity analytical reference standard (≥99.73%) designed for precise qualitative and quantitative analysis in research laboratories. This compound is a biologically active metabolite of vitamin A, widely used in cell biology, pharmacology, and molecular research.
Retinoic acid plays a critical role in cell differentiation, proliferation, and embryonic development, and is a key regulator of gene expression via nuclear receptor signaling pathways.
Key Features
- High-purity analytical standard (≥99.73%)
- Widely recognized as all-trans-Retinoic acid (ATRA)
- Suitable for HPLC, GC, and LC-MS/MS analysis
- Functions as a RAR (Retinoic Acid Receptor) agonist
- Binds PPARβ/δ (Kd ≈ 17 nM)
- Inhibits Nrf2 transcription factor via RARα activation
- Supplied in multiple pack sizes for research flexibility
Applications
- Analytical standard for chromatographic methods (HPLC, GC, LC-MS/MS)
- Research in cell differentiation and proliferation
- Studies in developmental biology and organogenesis
-
Pharmacological research involving:
- RAR signaling pathways
- PPARβ/δ modulation
- Molecular biology and gene regulation studies
Technical Specifications
| Parameter | Specification |
|---|---|
| Product Name | Retinoic Acid (Standard) |
| Synonyms | Vitamin A acid, ATRA |
| CAS Number | 302-79-4 |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 g/mol |
| Purity | ≥99.73% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| Structure Class | Carboxylic acid (retinoid) |
| Product Type | Analytical Standard |
| Application | HPLC, GC, MS |
| Shipping | Room temperature |
| Storage | As per COA |
Available Pack Sizes
| Size | Catalog Number |
|---|---|
| 5 mg | HY-14649R-5MG |
| 10 mg | HY-14649R-10MG |
| 25 mg | HY-14649R-25MG |
| 50 mg | HY-14649R-50MG |
| 100 mg | HY-14649R-100MG |
| 250 mg | HY-14649R-250MG |
| 500 mg | HY-14649R-500MG |
Mechanism of Action
- Acts as a ligand for Retinoic Acid Receptors (RARα, β, γ) with IC₅₀ ≈ 14 nM
- Modulates gene expression by binding to nuclear receptors
- Interacts with PPARβ/δ, influencing lipid metabolism and cell signaling
- Regulates transcription pathways including Nrf2 inhibition
This Retinoic Acid standard offers high analytical accuracy and biological relevance, making it ideal for laboratories conducting advanced molecular, pharmacological, and analytical research. Its high purity and well-characterized activity ensure reliable and reproducible results.
The Retinoic Acid (ATRA) Analytical Standard is a critical compound for laboratories engaged in biochemical, pharmaceutical, and analytical research. With its defined biological activity and high purity, it supports precision analysis and advanced scientific investigations.
- Pack Size: 25mg 5 mg 50 mg 100 mg 500 mg 250 mg 10 mg