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LG Standards Cycloguanil Embonate
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Antimalarial API
Specifications:
| Application | cell Signalling | ||
| Storage Temperature | 2-8°C | ||
| Product Type | Antiparasitics | Forms | Solid |
| Product Brand | LGC Standards | ||
| Product Grade | Analytical grade | Formula | C₂₃H₁₆O₆ · 2 C₁₁H₁₄ClN₅ |
Cycloguanil Embonate is a certified pharmaceutical reference material (CRM) supplied by LGC for use in analytical testing, method validation, quality control, and research related to antimalarial active pharmaceutical ingredients (APIs).
It is the embonate (pamoate) salt of cycloguanil, a biologically active metabolite of proguanil, widely studied and applied in antimalarial drug development and quality assurance workflows. The embonate form is particularly valued for its stability and suitability as a reference standard in analytical laboratories.
This material is produced and characterized in compliance with ISO 17034, ensuring traceability, accuracy, and reproducibility for regulated environments.
Intended Use
- For laboratory and research use only
- Not for human or veterinary administration
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Suitable for:
- API identification and confirmation
- HPLC / LC-MS / GC-MS method development
- Assay validation and system suitability testing
- Pharmaceutical quality control
- Antimalarial drug research
Chemical & Analytical Information
| Property | Specification |
|---|---|
| Analyte Name | Cycloguanil Embonate |
| CAS Number | 609-78-9 |
| Molecular Formula | C₂₃H₁₆O₆ · 2 C₁₁H₁₄ClN₅ |
| Molecular Weight | 891.80 g/mol |
| Accurate Mass | 890.2822 |
| Drug Class | Antiparasitics (Antimalarials) |
| API Family | Cycloguanil Embonate |
| Product Type | API Reference Standard |
Structure Information
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SMILES:
CC1(C)N=C(N)N=C(N)N1c2ccc(Cl)cc2.CC3(C)N=C(N)N=C(N)N3c4ccc(Cl)cc4.OC(=O)c5cc6ccccc6c(Cc7c(O)c(cc8ccccc78)C(=O)O)c5O -
IUPAC Name:
4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid; 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine
Pharmaceutical & Scientific Relevance
- Cycloguanil is the active metabolite of proguanil, a cornerstone antimalarial agent
-
Embonate (pamoate) salt form enhances:
- Analytical stability
- Handling consistency
- Suitability as a reference standard
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Used extensively in:
- Antimalarial formulation studies
- Stability and degradation testing
- Comparative pharmacopoeial analysis
Applications
- Pharmaceutical quality control laboratories
- API assay and impurity profiling
- Antimalarial drug research and development
- Reference standard calibration
- Regulatory and compliance testing (GMP / GLP environments)
Storage & Shipping
| Parameter | Condition |
|---|---|
| Storage Temperature | +5 °C |
| Shipping Temperature | Room Temperature |
| Format | Neat |
| Stability | Refer to Certificate of Analysis |
Quality & Compliance
- Manufactured under ISO 17034 accreditation
- Supplied with Certificate of Analysis (CoA)
- Full traceability and batch documentation
- Suitable for regulated pharmaceutical laboratories
Product Classification
- Product Category: API Reference Standards & Research Materials
- Sub-category: Antimalarials
- Drug Type: Antiparasitics
LGC Cycloguanil Embonate (50 mg) is a high-quality, ISO-17034-certified API reference standard designed for accurate, reproducible analytical work in antimalarial research and pharmaceutical quality control. Its proven stability, traceability, and regulatory alignment make it an essential material for method validation, API testing, and compliance-driven laboratories.